Authors : Azab Mohammed , Issam Mayyas , Ahmed Elbetieha , Ali shoter , Wael Khamas and Ziad Elnasser
Abstract: Twelve weeks ingestion of aluminium chloride via drinking water by adult non-pregnant female mice induced adverse effects on reproduction and fertility. Aluminium chloride induced a significant decrease in pregnancy rate and a significant increase in number of females with resorptions and in number of resorptions. Furthermore, histological changes in ovarian sections from adult non-pregnant female mice confirmed the reproductive toxicity of aluminium chloride. Highly congested blood vessels all over the ovary, with large number of atretic follicles at different stages of development have been seen. Also, highly congested blood vessels with necrotic and degenerative area in liver and kidney sections was observed. Intraperitoneal injection of aluminium chloride during day 0-6 of pregnancy caused a significant increase in pregnancy failure, number of females with resorptions and number of resorptions. Besides, a significant decrease in number of viable fetus and number of implantation site were recorded. The results indicated that ingestion of aluminium chloride by adult female mice would cause adverse effects on fertility and reproduction.
Azab Mohammed , Issam Mayyas , Ahmed Elbetieha , Ali shoter , Wael Khamas and Ziad Elnasser , 2008. Toxicity Evaluation of Aluminium Chloride on Adult Female Mice. Journal of Animal and Veterinary Advances, 7: 552-556.