Abstract: This study proposes a new algorithm of color image encryption depend on Deoxyribo Nucleic Acid (DNA) and a novel 3-dimentianal chaotic system. The chaotic system was tested by calculating the Lyapunov exponents where show that it has one positive value which means that it is chaotic and the system's sensitivity to the initial values has been proved. By using operation XOR between the random values got from the novel chaotic method and DNA encoding for plain image. The same operation will be done by chaotic sequences. So that, we determine some operation rules which can be utilized between plain image and chaotic sequences. The proposed algorithm has been experimentally evaluated where it has large key space and the encryption algorithm has high resistance to statistical attacks where histogram test for encrypted image is completely uniform and correlation values for encrypted image is small and about to zero while the entropy values for encrypted image are close to optimal value, the encryption algorithm also has high resistance to differential attack where the values for Number of Changing Pixel Rate (NPCR) and Unified Averaged Changed Intensity (UACI) is pass the all theoretical intervals and in addition to that the encryption algorithm has good sensitivity to key change and the time image encryption/decryption was very small, all these improves the security and can resist most popular attacks which appears that proposed algorithm has a perfect security.