Authors : Atul Upreti, Anjani Kumar Srivastava, Vimalkumar Mappilettu Balan and Kamal Kumar Saxena
Abstract: Several subtypes of Gonadotropin Releasing Hormone (GnRH) and its receptor are known in non-mammalian vertebrates but the only functional GnRH receptor known in higher mammals so far is type-I GnRH receptor. Though GnRH is primarily known for its role in the regulation of gonadotropins (FSH and LH) secretion from the pituitary, it is also though to be an autocrine/paracrine regulator of ovarian functions. Receptor of gonadotropin releasing hormone is well studied in several animal species but no study has been made to explore the role of GnRH receptor in extrahypophysial tissues of goat. Here we report, for the first time the confirmation of expression of type-I GnRH receptor in the ovary and uterus of goat. The expression of this receptor in these tissues was confirmed by RT-PCR and western blotting.
Atul Upreti, Anjani Kumar Srivastava, Vimalkumar Mappilettu Balan and Kamal Kumar Saxena, 2011. Presence of Type-I Gonadotropin Releasing Hormone Receptor Transcript and Protein in Ovary and Uterus of Goat (Capra hircus). Journal of Molecular Genetics, 3: 8-11.