Authors : Mohammad Mehdi Hoseinian and Yousef Nayebzadeh
Abstract: One of the most common human neurodegenerative disorders, second only to Alzheimer disease, Parkinson Disease (PD) proves to be a diagnostic and therapeutic challenge in medical practice. Significant advances have been made in definin g its pathogenesis and pathology and in turn, in the development of therapeutic interventions designed to maximize control of symptoms while minimizing long-term disability and treatment related complications. The aim of this study was to comparative assessment in effectiveness of levodopa and levodopa plus restin in treatment of patients with Parkinson ’s disease referred to hospital. In this study, 40 patients with Parkinson disease were divided into 2 groups of 20. This study carried out from September until November, 2011 for 3 months. Based on data showed in the result, it has been revealed that combination use of levodopa plus restin showed better results than single use of levodopa. Finally can be state that the control of Parkinsonian symptoms in patients with dopamine agonists concomitant with levodopa therapy has been successful.
Mohammad Mehdi Hoseinian and Yousef Nayebzadeh, 2012. Comparative Assessment in Effectiveness of Levodopa and Levodopa plus Pramipexole (Restin) in Treatment of Patients with Parkinson ’s Disease Referred to Hospital. Research Journal of Biological Sciences, 7: 23-30.