Authors : Mohamad I. Jarrah, Mahasen S. AL- Najar, Sulaiman Al Momany and Ashraf O. Owais
Abstract: This review study focused the attention on understanding the similarities between cardiac diseases and cancer through molecular mechanisms. We investigated the molecular effects of suppressor gene p53. The p53 is a tumor suppressor gene and its role is to maintain normal growth control and genomic stability. The importance of p53 comes from the fact that its mutations are involved in all major human cancers. In case of uncontrolled growth, p53 acts as a transcription factor for several genes to promote apoptosis. It has also been shown that p53 has important non-transcriptional effects on apoptosis which implies the involvement of its ability to repress anti-apoptotic or activate pro-apoptotic Bcl-2 family members. Studies have pointed to a link between cardiac diseases and cancer through displaying an imbalance of progrowth mechanisms.
Mohamad I. Jarrah, Mahasen S. AL- Najar, Sulaiman Al Momany and Ashraf O. Owais, 2014. The Relationship Between Cardiovascular Diseases and Cancer Through Understanding the Molecular Roles of p53. Research Journal of Biological Sciences, 9: 220-222.