Abstract: In Sudan, the visceral leishmaniasis hyper-endemic foci are mainly in east and south of the country. Cutaneous leishmaniasis is mainly found in northern and western regions beside scattered foci in central part of the country. The Green Valley villages are situated in Nuba Mountain region, South Kordofan province; 600 km west from the capital Khartoum. These villages have been deserted for 20 years (from seventies to nineties) due to a killing disease which was called by the villagers (Marrad Alsayeed) and described as a disease brought by the dust created by the movement of cattle and camels. Lately as the villagers resettled back during late nineties a similar disease reappeared among them affecting all age groups. Leishmanin Skin Test (LST) was conducted to all villagers as a screening test on three consecutive field visits August, October and February which resemble pre-raining season, raining and post raining seasons. Which reflect the transmission load according to the breeding of sandflies, the leishmaniasis vector.