Abstract: The effect of ethanolic extract of Blighia sapida on male reproductive hormones, semen parameters, testicular morphometrics, serum biochemical indices and prostate specific antigen in male wistar rats was studied. Twenty-four male wistar rats (200-220 g, n = 6) were randomly selected into four study groups, A, B, C and D. Animals in group A (control) received 1 mL of distilled water (vehicle) and test groups B, C and D received (orally) graded doses of 100, 200 and 300 mg kg^-1 BW of ethanolic extract of Blighia sapida respectively for 21 days after which they were sacrificed by cervical dislocation. Blood samples were collected via cardiac puncture for determination of serum testosterone and leutinizing hormones, cholesterol, triglycerides, prostate specific antigen and glutamate pyruvate transaminase levels. The testis was isolated for its morphometry and the caudal epididymis separated for semen analysis. The testosterone level, testicular length and width, percentage of motile sperm, sperm with normal morphology and active sperm significantly (p<0.05) increased in group C compared with the other groups. The total sperm count, Serum glutamate transaminase, cholesterol and triglyceride levels increased in a dose dependent pattern in the treatment groups and Prostate specific antigen was least in group C. It can be concluded that Blighia sapida may have the potential of stimulating male reproduction. It may therefore be recommended that a dose of 200 mg kg^-1 BW of the extract be considered in the management of male reproductive dysfunction.