Authors : V.M. Thorat and Jaydeep M. Bairagi
Abstract: The calcium channel blockers flunarizine, comparing the inhibitory effects of nifedipine and their efficacy with sodium valproate are induced in MES and PTZ in broad-spectrum anticonvulsant Alzheimer’s mice. Calcium ion and its entry play an important role in origin of seizures. The objective of the study is to investigate effect of cerebro selective Calcium Channel Blockers (CCBs), flunarizine and nimodipine with three different dosages and sodium valproate with one dose on MES (Maximal Electroshock Seizures) and PTZ (Pentylenetetrazol) induced convulsions in wistar rats. The CCBs have established themselves as very effective therapeutic agents in various disorders of the cardiovascular system like systemic hypertension, supraventricular arrhythmias, angina pectoris, etc., in central nervous system like migraine, vertigo, subarachnoid hemorrhage, etc. and for reversal of resistance in chemotherapy. In this study, the pre-clinical evaluation for anticonvulsant profile of cerebro selective CCBs viz. Flunarizine and Nimodipine and their comparison with standard drug sodium valproate using conventional models of experimental epilepsy, i.e. by MES and PTZ induced seizures in wistar rats.
V.M. Thorat and Jaydeep M. Bairagi, 2015. Comparison of the Anticonvulsant Effect of Flunarizine, Nimodipine and Sodium Valproate in Rats. Research Journal of Medical Sciences, 9: 314-318.