Abstract: Endothelial dysfunction is considered as an essential role within the pathogenesis of systemic hypertension. Several factors involved in evolution of endothelial dysfunction including traditional cardiovascular risk factor had been claimed. Modulation of these factors specially the reversible factors may give us important ways for prevention of hypertension and its comorbidities in patients at risk of developing hypertension. The purpose of this study is to determine the association among brachial artery flow mediated dilation with the Cardiovascular risk factors in prehypertensive patients. In this study, 112 pre-hypertensive patients were analyzed. For each patients a full medical history including the age, gender, BMI, smoking history, physical inactivity and family history of premature CVD, followed by comprehensive physical examination was done after which a blood sample was withdrawn for estimation of FBS, total and LDL, serum cholesterol, serum HDL and TG After that each patient had been evaluated for brachial artery flow that mediated dilation. The results show that impaired BAFMD is significantly associated with FBS, TC, LDL, Cholesterol while there was no significant association with the age, TG, nor with HDL. Impaired BAFMD is also significantly associated with gender, obesity, physical inactivity, family history of premature CV disease and smoking status. Therefore, abnormalitis of BAFMD as index of endothelial dysfunction is significantly associated with multiple traditional cardiovascular risk factors even in prehypertensive stage of hypertension.