Authors : Rola S. Saqan, Ameer K. Alaraji, Rami S. AlAzab and Wasim Khasawneh
Abstract: Botulinum toxin-A has been used in the treatment of overactive bladder effectively. The objective of this study was to investigate the effects of using Botulinum Toxin-A (BoNT-A) in reducing the frequency of urinary tract infections. The 119 patients were included in this study. A retrospective design was conducted to collect data from patients who visited urology clinics at King Abdulla University Hospital. Results showed that the mean age of study participants was 25.80+22.63 years, among them were 35(29.4%) males, 68.1% of participants had at least one positive urine culture in the 6 months preceding the treatment. Among positive cultures, E. coli was the most prevalent organism (42.6%) and the rate of mixed growth was about 30%. Post-treatment urine cultures showed that about 44.5% were positive of which E. coli was the most prevalent (37%). The rate of mixed growth had increased to about 39.22%. Taken together, our study showed that using botulinum toxin-A is helpful in reducing urinary tract infection. Furthermore, botulinum toxin-A increased the frequency of mixed growth and we might speculate that using a prophylactic antibiotic course accompanied with its use is recommended.
Rola S. Saqan, Ameer K. Alaraji, Rami S. AlAzab and Wasim Khasawneh, 2017. The Impact of using Botulinum Toxin-A on Urinary Tract Infection in Patients with Overactive Bladder. Research Journal of Medical Sciences, 11: 186-190.