Abstract: Mindfulness Based Intervention (MBI.) is found in the practices of all beliefs, religions and cultures. The various styles can be divided in to 4 patterns: mindful breathing, mind-body, body scan guided image. Body healing mechanisms can be divided into the following groups, changes in neurotransmitters autonomous nervous system endocrine and immune system. With these mechanisms, we can reduce the sufferings of patients who are near the end of life stages such as dyspnea, pain, fear and anxiety. For patients who have limited body movements the following 6 steps are recommended, to accept their illness, to accept their deaths, to accept and sooth their inner emotions and thoughts, to be aware of what their bodies are going through, to be aware of one's own breathing, to converse with the whole body. The MBI. should be applied in the treatment process for patients near the end of their lives, especially upon admission at the hospital and it should be applied to those with chronic diseases. There are problems where conventional treatments do not receive do any response, e.g., SLE., HIV., emotion instability and bipolar disorder.