Authors : S.O. OKENIYI
Abstract: Salivary and plasma nifedipine concentrations were measured in 6 healthy volunteers. A correlation of 0.965 (P < 0.001) was observed between salivary and plasma nifedipine concentrations. The level of significance of maximum concentration (Cmax) between plasma and saliva was statistically significant (P < 0.001). Identical salivary and plasma nifedipine time to peak drug levels (tmax) was established. Peak salivary concentration (Cmax) ranged from 59.57ng to 63.90ng while peak plasma concentrations ranged from 35.95ng to 39.40ng. Results suggest salivary nifedipine concentration to be of value in bioavailability and pharmacokinetic studies.
S.O. OKENIYI , 2007. SALIVARY AND PLASMA CONCENTRATIONS OF NIFEDIPINE AFTER A SINGLE ORAL DOSE IN HEALTHY VOLUNTEERS. Research Journal of Pharmacology, 1: 27-29.