References

Alqasoumi, S.I., T.A. Al-Howiriny and M.S. Abdel-Kader, 2008. Evaluation of the hepatoprotective effect of Aloe vera, Clematis hirsute, Cucumis prophetarum and bee propolis against experimentally induced liver injury in rats. Int. J. Pharmacol., 4: 213-217.
CrossRef  |  Direct Link  |  

Boudreau, M.D. and F.A. Beland, 2006. An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), Aloe vera. J. Environ. Sci. Health Part C: Environ. Carcinog. Ecotoxicol. Rev., 24: 103-154.
CrossRef  |  PubMed  |  Direct Link  |  

Choi, S.W., B.W. Son, Y.S. Son, Y.I. Park, S.K. Lee and M.H. Chung, 2001. The wound-healing effect of a glycoprotein fraction isolated from Aloe vera. Br. J. Dermatol., 145: 535-545.
CrossRef  |  PubMed  |  Direct Link  |  

Choi, S.W., K.W. Kim, J.S. Choi, S.T. Han and Y.I. Park et al., 2002. Angiogenic activity of β-sitosterol in the ischaemia/reperfusion-damaged brain of Mongolian gerbil. Planta Med., 68: 330-335.
CrossRef  |  Direct Link  |  

Cosmetic Ingredient Review Expert Panel, 2007. Final report on the safety assessment of Aloe andongensis extract, Aloe andongensis leaf juice, Aloe arborescens leaf extract, Aloe arborescens leaf juice, Aloe arborescens leaf protoplasts, Aloe barbadensis flower extract, Aloe barbadensis leaf, Aloe barbadensis leaf extract, Aloe barbadensis leaf juice, Aloe barbadensis leaf polysaccharides, Aloe barbadensis leaf water, Aloe ferox leaf extract, Aloe ferox leaf juice and Aloe ferox leaf juice extract. Int. J. Toxicol., 26: 1-50.
CrossRef  |  PubMed  |  

Coviello, T., P. Matricardi, C. Marianecci and F. Alhaique, 2007. Polysaccharide hydrogels for modified release formulations. J. Control Release, 119: 5-24.
CrossRef  |  PubMed  |  

Dagne, E., D. Bisrat, A. Viljoen and B.E. Van Wyk, 2000. Chemistry of Aloe species. Curr. Org. Chem., 4: 1055-1078.
CrossRef  |  Direct Link  |  

Davis, R.H., M.G. Leitner, J.M. Russo and M.E. Byrne, 1989. Wound healing. Oral and topical activity of aloe vera. J. Am. Podiatr. Med. Assoc., 79: 559-562.
PubMed  |  Direct Link  |  

Desmouliere, A., A. Geinoz, F. GabbianI and G. GabbianI, 1993. Transforming growth factor-1 induces-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J. Cell Biol., 122: 103-111.

Eshun, K. and Q. He, 2004. Aloe vera: A valuable ingredient for the food, pharmaceutical and cosmetic industries -A review. Crit. Rev. Food Sci. Nutr., 44: 91-96.

Fei, Y.M., J. Zainol, A.G. Pillay and N. Yusof, 2002. Experimental evaluation of healing process of burn-wound treated by lyophilized aloe vera dressing. J. Medical Sci., 2: 1-6.
CrossRef  |  Direct Link  |  

Femenia, A., E.S. Sanchez, S. Simal and C. Rosello, 1999. Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydr. Polym., 39: 109-117.
CrossRef  |  

Frank, S., G. Hubner, G. Dreier, M.T. Longaker, D.G. Greenhalgh and S. Werner, 1995. Regulation of vascular endothelial growth factor expression in cultured keratinocytes: Implications for normal and impaired wound healing. J. Biol. Chem., 270: 12607-12613.
Direct Link  |  

Golden, M.H.N., B.E. Golden and A.A. Jackson, 1980. Skin breakdown in kwashiorkor responds to zinc. Lancet, 315: 1256-1256.
CrossRef  |  Direct Link  |  

Habeeb, F., E. Shakir, F. Bradbury, P. Cameron and M.R. Taravati et al., 2007. Screening methods used to determine the anti-microbial properties of Aloe vera inner gel. Methods, 42: 315-320.
CrossRef  |  

Haley, J.V., 1979. Zinc sulfate and wound healing. J. Surg. Res., 27: 168-174.
CrossRef  |  Direct Link  |  

Hasani-Ranjbar, S., B. Larijani and M. Abdollahi, 2011. Recent update on animal and human evidences of promising antidiabetic medicinal plants: A mini-review of targeting new drugs. Asian J. Anim. Vet. Adv., 6: 1271-1275.
CrossRef  |  Direct Link  |  

He, Q., L. Changhong, E. Kojo and Z. Tian, 2005. Quality and safety assurance in the processing of Aloe vera gel juice. Food Control, 16: 95-104.
CrossRef  |  Direct Link  |  

Jani, G.K., D.P. Shah, V.C. Jain, M.J. Patel and D.A. Vithalan, 2007. Evaluating mucilage from Aloe Barbadensis Miller as a pharmaceutical excipient for sustained-release matrix tablets. Pharm. Technol., 31: 90-98.

Liu, C., M.Y. Leung, J.C. Koon, L.F. Zhu, Y.Z. Hui, B. Yu and K.P. Fung, 2006. Macrophage activation by polysaccharide biological response modifier isolated from Aloe vera L. var. chinensis (Haw.). Berg. Int. J. Immunopharmacol., 6: 1634-1641.
PubMed  |  

Moon, E.J., Y.M. Lee, O.H. Lee, M.J. Lee and S.K. Lee et al., 1999. A novel angiogenic factor derived from Aloe vera gel: sitosterol, a plant sterol. Angiogenesis, 3: 117-123.
PubMed  |  

Mustoe, T.A., G.F. Pierce, C. Morishima and T.F. Deuel, 1991. Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. J. Clin. Invest., 87: 694-703.
CrossRef  |  

Newton, L.E., 2004. Aloes in Habitat. In: Aloes The Genus Aloe, Reynolds, T. (Ed.). CRC Press, Boca Raton, pp: 3-36.

Ni, Y. and I.R. Tizard, 2004. Analytical Methodology: The Gel-Analysis of Aloe Pulp and its Derivatives. In: Aloes the Genus Aloe, Reynolds, T. (Ed.). CRC Press, Boca Raton, FL., USA., pp: 111-126.

Ni, Y., D. Turner, K.M. Yates and I. Tizard, 2004. Isolation and characterization of structural components of Aloe vera L. leaf pulp. Int. Immunopharmacol., 4: 1745-1755.
CrossRef  |  Direct Link  |  

Ni, Y., K.M. Yates and I.R. Tizard, 2004. Aloe Polysaccharides. In: Aloes The Genus Aloe, Reynolds, T. (Ed.). CRC Press, Boca Raton, pp: 75-87.

Pan, S., P. An, R. Zhang, X. He, G. Yin and W. Min, 2002. Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: Role in endothelial cell migration and angiogenesis. Mol. Cell. Biol., 22: 7512-7523.
CrossRef  |  Direct Link  |  

Prasad, A.S. and D. Oberleas, 1974. Thymidine kinase activity and incorporation of thymidine into DNA in zinc-deficient tissue. J. Lab. Clin. Med., 83: 634-639.
PubMed  |  

Qiu, Z., K. Jones, M. Wylie, Q. Jia and S. Orndorff, 2000. Modified Aloe barbadensis polysaccharide with immuneregulatory activity. Planta Med., 66: 152-156.
PubMed  |  

Reynolds, T., 2004. Aloe Chemistry. In: Aloes The Genus Aloe, Reynolds, T. (Ed.). CRC Press, Boca Raton, pp: 39-74.

Saka, W.A., R.E. Akhigbe, O.S. Ishola, E.A. Ashamu, O.T. Olayemi and G.E. Adeleke, 2011. Hepatotherapeutic effect of Aloe vera in alcohol-induced hepatic damage. Pak. J. Biol. Sci., 14: 742-746.
CrossRef  |  

Sandstead, H.H., V.C. Lanier, G.H. Shephard and D.D. Gillespie, 1970. Zinc and wound healing: Effects of zinc deficiency and zinc supplementation. Am. J. Clin. Nutr., 23: 514-519.
PubMed  |  

Sinha, V.R. and R. Kumria, 2001. Polysaccharides in colon-specific drug delivery. Int. J. Pharm., 224: 19-38.
Direct Link  |  

Stromberg, H.E. and M.S. Agren, 1984. Topical zinc oxide treatment improves arterial and venous leg ulcers. Br. J. Dermatol., 111: 461-468.
CrossRef  |  Direct Link  |  

Talmadge, J., J. Chavez, L. Jacobs, C. Munger and T. Chinnah et al., 2004. Fractionation of Aloe vera L. inner gel, purification and molecular profiling of activity. Int. Immunopharmacol., 414: 1757-1773.
PubMed  |  

Vazquez, B., G. Avila, D. Segura and B. Escalante, 1996. Anti-inflammatory activity of extracts from Aloe vera gel. J. Ethnopharmacol., 55: 69-75.
CrossRef  |  PubMed  |  Direct Link  |  

Vinson, J.A., H. Al Kharrat and L. Andreoli, 2005. Effect of Aloe vera preparations on the human bioavailability of vitamins C and E. Phytomedicine, 12: 760-765.
CrossRef  |  PubMed  |  Direct Link  |