References

Barnes, S., 2010. The biochemistry, chemistry and physiology of the isoflavones in soybeans and their food products. Lymphat. Res. Biol., 8: 89-98.
CrossRef  |  PubMed  |  

Di Virgilio, A.L., K. Iwami, W. Watjen, R. Kahl and G.H. Degen, 2004. Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells. Toxicol. Lett., 151: 151-162.
CrossRef  |  

Engel, N., J. Lisec, B. Piechulla and B. Nebe, 2012. Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A. PLoS ONE, Vol. 7. 10.1371/journal.pone.0047833

Fellows, M.D., A.T. Doherty, C.C. Priestley, V. Howarth and M.R. O'Donovan, 2011. The ability of the mouse lymphoma TK assay to detect aneugens. Mutagenesis, 26: 771-781.
CrossRef  |  

Fox, J.T., S. Sakamuru, R. Huang, N. Teneva and S.O. Simmons et al., 2012. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. USA., 109: 5423-5428.
CrossRef  |  

Gencel, V.B., M.M. Benjamin, S.N. Bahou and R.A. Khalil, 2012. Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease. Mini Rev. Med. Chem., 12: 149-174.
CrossRef  |  

Hertrampf, T., M.J. Gruca, J. Seibel, U. Laudenbach, K.H. Fritzemeier and P. Diel, 2007. The bone-protective effect of the phytoestrogen genistein is mediated via ERα-dependent mechanisms and strongly enhanced by physical activity. Bone, 40: 1529-1535.
CrossRef  |  

Honma, M., L.Z. Zhang, H. Sakamoto, M. Ozaki and K. Takeshita et al., 1999. The need for long-term treatment in the mouse lymphoma assay. Mutagenesis, 14: 23-29.
CrossRef  |  

Honma, M., M. Hayashi, H. Shimada, N. Tanaka and S. Wakuri et al., 1999. Evaluation of the mouse lymphoma TK assay (microwell method) as an alternative to the in vitro chromosomal aberration test. Mutagenesis, 14: 5-22.
CrossRef  |  

Honma, M., M. Momose, H. Sakamoto, T. Sofuni and M. Hayashi, 2001. Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction. Mutation Res./Genet. Toxicol. Environ. Mutagen., 493: 101-114.
CrossRef  |  

Lloyd, M. and D. Kidd, 2012. The Mouse Lymphoma Assay. In: Genetic Toxicology: Principles and Methods, Parry, J.M. and E.M. Parry (Eds.). Springer, New York, USA., ISBN-13: 9781617794209, pp: 35-54.

McClain, R.M., E. Wolz, A. Davidovich and J. Bausch, 2006. Genetic toxicity studies with genistein. Food Chem. Toxicol., 44: 42-55.
CrossRef  |  

Morris, S.M., J.J. Chen, O.E. Domon, L.J. McGarrity, M.E. Bishop, M.G. Manjanatha and D.A. Casciano, 1998. p53, mutations and apoptosis in genistein-exposed human lymphoblastoid cells. Mutation Res./Fundam. Mol. Mech. Mutagen., 405: 41-56.
CrossRef  |  

Ogawa, I., S. Furukawa, M. Abe, Y. Tanaka, S. Hayashi and K. Usuda, 2009. Multi-endpoint genotoxic assay using L5178Y (Tk^+/--3.7.2c) cells. J. Toxicol. Sci., 34: 547-553.
Direct Link  |  

Ouyang, G., L. Yao, K. Ruan, G. Song, Y. Mao and S. Bao, 2009. Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. Cell Biol. Int., 33: 1237-1244.
CrossRef  |  

Rozman, K.K., J. Bhatia, A.M. Calafat, C. Chambers and M. Culty et al., 2006. NTP-CERHR expert panel report on the reproductive and developmental toxicity of genistein. Birth Defects Res. Part B: Dev. Reprod. Toxicol., 77: 485-638.
CrossRef  |  

Schmidt, F., C.B. Knobbe, B. Frank, H. Wolburg and M. Weller, 2008. The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. Oncol. Rep., 19: 1061-1066.
PubMed  |  Direct Link  |  

Stopper, H., E. Schmitt and K. Kobras, 2005. Genotoxicity of phytoestrogens. Mutat. Res., 574: 139-155.

Taylor, C.K., R.M. Levy, J.C. Elliott and B.P. Burnett, 2009. The effect of genistein aglycone on cancer and cancer risk: A review of in vitro, preclinical and clinical studies. Nutr. Rev., 67: 398-415.
CrossRef  |  

Wang, J., J.R. Sawyer, L. Chen, T. Chen, M. Honma, N. Mei and M.M. Moore, 2009. The mouse lymphoma assay detects recombination, deletion and aneuploidy. Toxicol. Sci., 109: 96-105.
CrossRef  |  

Weng, C., J. Cai, J. Wen, H. Yuan, K. Yang, J. Imperato-McGinley and Y.S. Zhu, 2013. Differential effects of estrogen receptor ligands on regulation of dihydrotestosterone-induced cell proliferation in endothelial and prostate cancer cells. Int. J. Oncol., 42: 327-337.
CrossRef  |  PubMed  |