References

Aoki, K., H. Taniguchi, Y. Ito, S. Satoh and S. Nakamura et al., 2004. Dehydroepiandrosterone decreases elevated hepatic glucose production in C57BL/KsJ-db/db mice. Life Sci., 74: 3075-3084.
CrossRef  |  

Arlt, W., J. Haas, F. Callies, M. Reincke and D. Hubler et al., 1999. Biotransformation of oral dehydroepiandrosterone in elderly men: Significant increase in circulating estrogens. J. Clin. Endocrinol. Metab., 84: 2170-2176.
Direct Link  |  

Arnold, J.T., N.E. Gray, K. Jacobowitz, L. Viswanathan and P.W. Cheung et al., 2008. Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells. J. Steroid Biochem. Mol. Biol., 111: 240-246.
CrossRef  |  

Bourguiba, S., S. Lambard and S. Carreau, 2003. Steroids control the aromatase gene expression in purified germ cells from the adult male rat. J. Mol. Endocrinol., 31: 83-94.
CrossRef  |  Direct Link  |  

Brock, B.J. and M.R. Waterman, 1999. Biochemical differences between rat and human cytochrome p450c17 support the different steroidogenic needs of these two species. Biochemistry, 38: 1598-1606.
CrossRef  |  

Frye, R.F., P.D. Kroboth, F.J. Kroboth, R.A. Stone and M. Folan et al., 2000. Sex differences in the pharmacokinetics of dehydroepiandrosterone (DHEA) after single- and multiple-dose administration in healthy older adults. J. Clin. Pharmacol., 40: 596-605.
PubMed  |  

Genazzani, A.D., C. Lanzoni and A.R. Genazzani, 2007. Might DHEA be considered a beneficial replacement therapy in the elderly? Drug Aging, 24: 173-185.
CrossRef  |  Direct Link  |  

Haider, S.G., 2004. Cell biology of leydig cells in the testis. Int. Rev. Cytol., 233: 181-241.
CrossRef  |  

Kroboth, P.D., J.A. Amico, R.A. Stone, M. Folan and R.F. Frye et al., 2003. Influence of DHEA administration on 24-hour cortisol concentrations. J. Clin. Pharmacol., 23: 96-99.
PubMed  |  

Labrie, F., A. Belanger, P. Belanger, R. Berube and C. Martel et al., 2007. Metabolism of DHEA in postmenopausal women following percutaneous administration. J. Steroid Biochem. Mol. Biol., 103: 178-188.
CrossRef  |  

Labrie, F., V. Luu-The, C. Labrie and J. Simard, 2001. DHEA and its transformation into androgens and estrogens in peripheral target tissues: Intracrinology. Front. Neuroendocrinol., 22: 185-212.
CrossRef  |  PubMed  |  Direct Link  |  

Leblanc, M., C. Labrie, A. Belanger, B. Candas and F. Labrie, 2002. Pharmacokinetics of oral dehydroepiandrosterone (DHEA) in the ovariectomised cynomolgus monkey. J. Steroid Biochem. Mol. Biol., 81: 159-164.
CrossRef  |  

Leblanc, M., C. Labrie, A. Belanger, B. Candas and F. Labrie, 2003. Bioavailability and pharmacokinetics of dehydroepiandrosterone in the cynomolgus monkey. J. Clin. Endocrinol. Metab., 88: 4293-4302.
CrossRef  |  Direct Link  |  

Majewska, M.D., 1995. Neuronal actions of dehydroepiandrosterone possible roles in brain development, aging, memory and affect. Ann. N.Y. Acad. Sci., 774: 111-120.
CrossRef  |  

Payne, A.H. and D.B. Hales, 2004. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocrine Rev., 25: 947-970.
CrossRef  |  PubMed  |  Direct Link  |  

Ping, L., R.A. Neill, S. Cardin, M. Survant and S. Davis, 2000. Dehydroepiandrosterone (DHEA) preserves counterregulatory responses during repeated hypoglycemia (hypo) in conscious normal rats. Diabetes, 49: A65-A66.

Sato, K., M. Iemitsu, K. Aizawa, N. Mesaki, R. Ajisaka and S. Fujita, 2012. DHEA administration and exercise training improves insulin resistance in obese rats. Nutr. Metab., Vol. 9. 10.1186/1743-7075-9-47

Savineau, J.P., R. Marthan and E.D. de la Roque, 2013. Role of DHEA in cardiovascular diseases. Biochem. Pharmacol., 85: 718-726.
CrossRef  |  

Schmidt, K.S., C.S. Stachel and P. Gowik, 2009. In-house validation and factorial effect analysis of a liquid chromatography-tandem mass spectrometry method for the determination of steroids in bovine muscle. Analytica Chimica Acta, 637: 156-164.
CrossRef  |  

Shen, X., L. Liu, F. Yin, H. Ma and S. Zou, 2012. Effect of dehydroepiandrosterone on cell growth and mitochondrial function in tm-3 cells. Gen. Comp. Endocrinol., 177: 177-186.
CrossRef  |  Direct Link  |  

Song, L.J., X. Tang, Y.L. Kong, H.T. Ma and S.X. Zou, 2010. The expression of serum steroid sex hormones and steroidogenic enzymes following the intraperitoneal administration of dehydroepiandrosterone (DHEA) in male rats. Steroids, 75: 213-218.
CrossRef  |