References

Aditya, V.S., N.L. Kumar and A.L. Mokkapati, 2013. In vitro anti-cancer activities of few plant extracts against MCF-7 and HT-29 cell lines. Int. J. Pharma. Sci., 3: 185-188.

Baroni, S., K.F. Suzuki, A.S.M. Caparroz, R.K.N. Cuman and C.A.A. Bersani, 2008. Effect of crude extracts of leaves of Smallanthus sonchifolius (yacon) on glycemia in diabetic rats. Rev. Bras. Cienc. Far., 44: 521-530.
Direct Link  |  

CRUK., 2016. Worldwide cancer statistics. London, UK., http://www.cancerresearchuk.org/health-professional/cancer-statistics/worldwide-cancer#6TbKXgZblk3S8lsv.99,

Cho, J.Y., A.R. Kim, J.H. Jung, T. Chun, M.H. Rhee and E.S. Yoo, 2004. Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines. Eur. J. Pharm., 492: 85-94.
CrossRef  |  PubMed  |  

Choi, N.H., J.B. Kim, J.T. Kim and I.S. Park, 2012. The effects of Yacon (Smallanthus sonchifolius) extract on pancreatic fibrosis in the rat. J. Life Sci., 22: 904-911.
CrossRef  |  Direct Link  |  

De Moura, N.A., B.F.R. Caetano, K. Sivieri, L.H. Urbano, C. Cabello, M.A.M. Rodrigues and L.F. Barbisan, 2012. Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis. Food Chem. Toxicol., 50: 2902-2910.
CrossRef  |  Direct Link  |  

De Moura, N.A., B.F.R. Caetano, K. Sivieri, L.H. Urbano, C. Cabello, M.A.M. Rodrigues and L.F. Barbisan, 2012. Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis. Food Chem. Toxicol., 50: 2902-2910.
CrossRef  |  Direct Link  |  

Fotakis, G. and J.A. Timbrell, 2006. In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol. Lett., 160: 171-177.
CrossRef  |  

Frank, F.M., J. Ulloa, S.I. Cazorla, G. Maravilla and E.L. Malchiodi et al., 2013. Trypanocidal Activity of Smallanthus sonchifolius: Identification of active sesquiterpene lactones by bioassay-guided fractionation. Evidence Based Complementary Altern. Med., Vol. 2013,

Genta, S., W. Cabrera, N. Habib, J. Pons, I.M. Carillo, A. Grau and S. Sanchez, 2009. Yacon syrup: Beneficial effects on obesity and insulin resistance in humans. Clin Nutr., 28: 182-187.
CrossRef  |  Direct Link  |  

Genta, S.B., W.M. Cabrera, M.I. Mercado, A. Grau, C.A. Catalan and S.S. Sanchez, 2010. Hypoglycemic activity of leaf organic extracts from Smallanthus sonchifolius: Constituents of the most active fractions. Chemico-Biol. Interact., 185: 143-152.
CrossRef  |  PubMed  |  Direct Link  |  

Ghantous, A., H. Gali-Muhtasib, H. Vuorela, N.A. Saliba and N. Darwiche, 2010. What made sesquiterpene lactones reach cancer clinical trials. Drug. Discov. Today, 15: 668-678.
PubMed  |  

Graefe, S., M. Hermann, I. Manrique, S. Golombek and A. Buerkert, 2004. Effects of post-harvest treatments on the carbohydrate composition of yacon roots in the Peruvian Andes. Field Crops Res., 86: 157-165.
Direct Link  |  

Grethel, D.T.C., W.M.D.S.C. Tamashiro, M.R. Marostica Junior and G.M. Pastore, 2013. Yacon (Smallanthus sonchifolius): A functional food. Plant Foods Hum. Nutr., 68: 222-228.
CrossRef  |  PubMed  |  Direct Link  |  

Habib, N.C., S.M. Honore, S.B. Genta and S.S. Sanchez, 2011. Hypolipidemic effect of Smallanthus sonchifolius (yacon) roots on diabetic rats: Biochemical approach. Chem. Biol. Interact., 194: 31-39.
PubMed  |  Direct Link  |  

Ishikawa, T., T. Hyakutake, Y. Gondou, M. Sakai and R. Kinoshita et al., 2010. Anti-Melanogenic Activity of Yacon Leaves in Mouse Melanoma Cells. In: Animal Cell Technology: Basic and Applied Aspects, Kamihira, M., Y. Katakura and A. Ito (Eds.). Springer, Netherlands, ISBN: 978-90-481-3891-3, pp: 359-364.

Min, K.J., J.U. Cheon and C.G. Cha, 2008. Anti-oxidative and anti-cancer activities of extracting of yacon. J. Food Hyg. Saf., 23: 163-168.
Direct Link  |  

Ojansivu, I., C.L. Ferreira and S. Salminen, 2011. Yacon, a new source of prebiotic oligosaccharides with a history of safe use. Trends Food Sci. Technol., 22: 40-46.
CrossRef  |  Direct Link  |  

Oliveira, G.O., C.P. Braga and A.A.H. Fernandes, 2013. Improvement of biochemical parameters in type 1 diabetic rats after the roots aqueous extract of yacon [Smallanthus sonchifolius (Poepp. & Endl.)] treatment. Food Chem. Toxicol., 59: 256-260.
PubMed  |  Direct Link  |  

Padla, E.P., L.T. Solis and C.Y. Ragasa, 2012. Antibacterial and antifungal properties of ent-kaurenoic acid from Smallanthus sonchifolius. Chin. J. Nat. Med., 10: 408-414.
Direct Link  |  

Pedreschi, R., D. Campos, G. Noratto, R. Chirinos and L. Cisneros-Zevallos, 2003. Andean yacon root (Smallanthus sonchifolius Poepp. Endl) fructooligosaccharides as a potential novel source of prebiotics. J. Agric. Food Chem., 51: 5278-5284.
CrossRef  |  PubMed  |  Direct Link  |  

Raga, D.D., A.B. Alimboyoguen, R.S. del Fierro and C.Y. Ragasa, 2010. Hypoglycaemic effects of tea extracts and ent-kaurenoic acid from Smallanthus sonchifolius. Nat. Prod. Res., 24: 1771-1782.
CrossRef  |  Direct Link  |  

Siriwan, D., C. Miyawaki, T. Miyamoto, T. Naruse, K. Okazaki and H. Tamura, 2011. Chemopreventive activity of sesquiterpene lactones (SLs) from yacon against TPA-induced Raji cells deformation. Pak. J. Biol. Sci., 14: 605-609.
CrossRef  |  Direct Link  |  

Siriwan, D., T. Naruse and H. Tamura, 2011. Effect of epoxides and α-methylene-γ-lactone skeleton of sesquiterpenes from yacon (Smallanthus sonchifolius) leaves on caspase-dependent apoptosis and NF- κB inhibition in human cercival cancer cells. Fitoterapia, 82: 1093-1101.
Direct Link  |  

Valentova, K. and J. Ulrichova, 2003. Smallanthus sonchifolius and Lepidium meyenii-prospective andean crops for the prevention of chronic diseases. Biomed. Pap., 147: 119-130.
PubMed  |  Direct Link  |  

Valentova, K., A. Lebeda, I. Dolezalova, D. Jirovsky and B. Simonovska et al., 2006. The biological and chemical variability of yacon. J. Agric. Food Chem., 54: 1347-1352.
PubMed  |  

Valentova, K., L. Cvak, A. Muck, J. Ulrichova and V. Simanek, 2003. Antioxidant activity of extracts from the leaves of Smallanthus sonchifolius. Eur. J. Nut., 42: 61-66.
CrossRef  |  Direct Link  |  

Velez, E., N. Castillo, O. Meson, A. Grau and M.E.B. Bonet et al., 2013. Study of the effect exerted by fructo-oligosaccharides from yacon (Smallanthus sonchifolius) root flour in an intestinal infection model with Salmonella Typhimurium. Br. J. Nutr., 109: 1971-1979.
CrossRef  |  PubMed  |  Direct Link  |