References

Anestopoulos, I., A. Kavo, I. Tentes, A. Kortsaris and M. Panayiotidis et al., 2013. Silibinin protects H9c2 cardiac cells from oxidative stress and inhibits phenylephrine-induced hypertrophy: Potential mechanisms. J. Nutrit. Biochem., 24: 586-594.
CrossRef  |  PubMed  |  Direct Link  |  

Bullon, P., H.N. Newman and M. Battino, 2014. Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: A shared pathology via oxidative stress and mitochondrial dysfunction? Periodontology, 64: 139-153.
CrossRef  |  PubMed  |  Direct Link  |  

Das, S., P. Roy, R. Pal, R.G. Auddy and A.S. Chakraborti et al., 2014. Engineered silybin nanoparticles educe efficient control in experimental diabetes. PloS One, Vol. 9,

Dayoub, R., A. Vogel, J. Schuett, M. Lupke and S.M. Spieker et al., 2013. Nrf2 activates Augmenter of Liver Regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration. Mol. Med., 19: 237-244.
CrossRef  |  PubMed  |  Direct Link  |  

Fellner, L., R. Irschick, K. Schanda, M. Reindl and L. Klimaschewski et al., 2013. Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia. Glia, 61: 349-360.
CrossRef  |  PubMed  |  Direct Link  |  

Gammella, E., S. Recalcati and G. Cairo, 2016. Dual role of ros as signal and stress agents: Iron tips the balance in favor of toxic effects. Oxid. Med. Cell. Longevity, 2016: 1-9.
PubMed  |  Direct Link  |  

Halliwell, B. and J.M. Gutteridge, 2015. Free Radicals In Biology And Medicine. 5th Edn., Oxford University Press, Oxford, England, USA., ISBN: 9780198717485, Pages: 905.

Hirst, J. and M.M. Roessler, 2016. Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I. Bioch. Biophys. Acta Bioenerg., 1857: 872-883.
CrossRef  |  PubMed  |  Direct Link  |  

Inzucchi, S.E., R.M. Bergenstal, J.B. Buse, M. Diamant and E. Ferrannini et al., 2012. Management of hyperglycemia in type 2 diabetes: A patient-centered approach position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care, 35: 1364-1379.
Direct Link  |  

Karas, D., R. Gaz-ak, K. Valentova, C.S. Chambers and V. Pivodova et al., 2016. Effects of 2, 3-dehydrosilybin and its galloyl ester and methyl ether derivatives on human umbilical vein endothelial cells. J. Nat. Prod., 79: 812-820.
CrossRef  |  PubMed  |  Direct Link  |  

Khan, M.A., B.H. Abbasi, N. Ahmed and H. Ali, 2013. Effects of light regimes on in vitro seed germination and silymarin content in silybum marianum. Ind. Crops Prod., 46: 105-110.
CrossRef  |  Direct Link  |  

Marzio, D.L.H.M. and J.M. Fenkel, 2014. Complementary and alternative medications in hepatitis C infection. World J. Hepatol., 6: 9-16.
Direct Link  |  

Oral, O., Y. Akkoc, O. Bayraktar and D. Gozuacik, 2016. Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis. Histol Histopathol, 31: 479-498.
PubMed  |  

Romero, A., R. Cacabelos, M.J.O. Gasque, A. Samadi and J.M. Contelles, 2013. Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease. Bioorg. Med. Chem. Lett., 23: 1916-1922.
CrossRef  |  Direct Link  |  

Sasaki, K. and M. Shimoda, 2015. Possible drug-drug interaction in dogs and cats resulted from alteration in drug: A mini review. J. Adv. Res., 6: 383-392.
CrossRef  |  Direct Link  |  

Schieber, M. and N.S. Chandel, 2014. ROS function in redox signaling and oxidative stress. Curr. Biol., 24: R453-R462.
CrossRef  |  Direct Link  |  

Subbaraj, G.K., L.A.N.G.E.S.W.A.R.A.N. Kulanthaivel, R. Rajendran and R. Veerabathiran, 2013. Ethanolic extract of carum carvi prevents N-nitrosodiethylamine induced phenobarbital promoted hepatocarcinogenesis by modulating antioxidant enzymes. Int. J. Pharm Pharm Sci., 5: 195-199.
Direct Link  |  

Surai, P.F., 2015. Antioxidant action of carnitine: Molecular mechanisms and practical applications. EC Vet. Sci., 2: 66-84.

Surai, P.F., 2015. Silymarin as a natural antioxidant: An overview of the current evidence and perspectives. Antioxidants, 4: 204-247.
CrossRef  |  PubMed  |  Direct Link  |  

Yang, X., L.K. Schnackenberg, Q. Shi and W.F. Salminen, 2014. Hepatic Toxicity Biomarkers. In: Biomarkers in Toxicology. Gupta, R.C. (Ed.). Elsevier, Amsterdam, Netherlands, pp: 241-259.

Yu, K., X.M. Li, X.L. Xu, R.Y. Zhang and H.L. Cong, 2015. Eupatilin protects against tumor necrosis factor-α-mediated inflammation inhuman umbilical vein endothelial cells. Int. J. Clin. Exp. Med., 8: 22191-22197.
PubMed  |  Direct Link  |  

Zhang, A., H. Sun and X. Wang, 2013. Recent advances in natural products from plants for treatment of liver diseases. Eur. J. Med. Chem., 63: 570-577.
CrossRef  |  Direct Link  |