Authors : Ayogu Ebere, Amorha Kosisochi, Okpalaoka Oluchukwu and Okonta Mathew
Abstract: The effect of ginger extract on the pharmacokinetic parameters of rifampicin and its penetration into the lung was investigated. Albino rats were used, Group A received rifampicin 10 mg kg–1 alone orally; Group B and C received 5 and 10 mg kg–1 of ginger extract respectively for 10 days and on day 11, 10 mg kgG1 rifampicin was given as in Group A. Blood samples were collected at different time and assayed to determine the concentration of rifampicin in the lungs tissues. Treatment with 5 mg kg–1 ginger significantly (p<0.05) increased Tmax by 93% and decreased Cmax, AUC, CL and t1/2 by 18, 13, 72 and 33%, respectively while 10 mg kg–1 resulted in a nonsignificant (p>0.05) increase in Tmax by 7% and decreased Cmax, AUC, t1/2 and CL by 8, 5, 59 and 77%. Concurrent administration of ginger and rifampicin resulted in significant (p>0.05) decrease in the concentration of rifampicin that penetrated the lung from 14.63×mn;4.06 in rifampicin alone to 9.99±4.06 and 9.14±0.97 for 5 and 10 mg kg–1 ginger. This study has shown that ginger caused significant change in the pharmacokinetic parameters of rifampicin when taken concurrently and also decreased concentration of rifampicin in the lungs.
Ayogu Ebere, Amorha Kosisochi, Okpalaoka Oluchukwu and Okonta Mathew, 2020. Evaluation of Zingiber officinale Effects on Rifampicin Pharmacokinetic Parameters using Animal Model. International Journal of Tropical Medicine, 15: 84-90.