Journal of Animal and Veterinary Advances

Year: 2009
Volume: 8
Issue: 11
Page No. 2329 - 2334

Polymorphism in 5' Regulatory Region of the Porcine Fat Mass and Obesity Associated (FTO) Gene is Associated with Intramuscular Fat Content in a Jinhua x Pietrain F2 Reference Population

Authors : Zhang Li-Fan, Miao Xiu-Ting, Hua Xu-Chuan, Jiang Xiao-Ling, Lu Yuan-Peng and Xu Ning-Ying

Abstract: As a newly described candidate gene in obesity, FTO gene showed a strong and highly significant association with the obesity-related traits in various human populations. It has been suggested that FTO gene play a key role in the regulation of energy balance and feed intake. Here we sequenced the -2.0 kb of the 5' flanking region of the porcine FTO gene, 7 SNPs were detected in this region and genotyped on the Jinhua x Pietrain F2 reference population. Using a gene-wide haplotype-tagging approach, three tag SNPs were examined. The SNPs of g -1191 A>G had significant associations with Intramuscular Fat (IMF) content (p<0.05), but not with the Average Backfat Thickness (ABF), Leaf Fat weight (LF) or Average Daily Gain (ADG). Additionally, allele frequencies of the g -1191A>G mutation were studied in 6 pig breeds and the G allele was mainly occurred in Chinese native pig breeds. These results provided the solid evidence that FTO gene was associated with the intramuscular fat deposition in pigs.

How to cite this article:

Zhang Li-Fan, Miao Xiu-Ting, Hua Xu-Chuan, Jiang Xiao-Ling, Lu Yuan-Peng and Xu Ning-Ying, 2009. Polymorphism in 5' Regulatory Region of the Porcine Fat Mass and Obesity Associated (FTO) Gene is Associated with Intramuscular Fat Content in a Jinhua x Pietrain F2 Reference Population. Journal of Animal and Veterinary Advances, 8: 2329-2334.

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