Abstract: Oral administration of carbon tetrachloride (CCl4) induces acute hepatitis while Prostaglandins (PGs) are proposed to attenuate liver injury. Conjugated Linoleic Acid (CLA) influences the synthesis of PGs and Arachidonic Acid (ARA) is a precursor of PGs. Therefore, whether CLA or ARA attenuates the hepatitis induced by CCl4 was investigated in mice. Male mice (age, 8 week) were given commercial diet and combinations of paraffin or CCl4 solution with or without CLA or ARA oil were orally administered. Food intake and body weight were significantly reduced in the CCl4 group. Although, no significant changes in liver weight were observed, liver triacylglycerol contents in the CCl4+CLA and CCl4+ARA groups were markedly higher than those in groups other than the CCl4 group. Plasma AST and ALT levels were unusually elevated after CCl4 administration irrespective of oil treatment. CCl4+ARA treatment greatly increased PGE2 content in the liver and followed by CCl4+CLA treatment. In conclusion, co-administration of CLA and ARA enhanced liver PGE2 levels after CCl4 treatment but acute hepatitis was not attenuated.
Daichi Oikawa, Yoriko Akimoto, Yurika Mizobe, Shoichiro Tsuyama and Mitsuhiro Furuse, 2010. Functions of CLA and ARA for Prevention of CCl4-Induced Fatty Liver in Mice. Journal of Animal and Veterinary Advances, 9: 2854-2858.