Abstract: The main aim of this study was to evaluate oral administration of Channa striatus extract on monosodium iodoacetate induced knee osteoarthritis changes in rat. About 40 rats were randomly assigned to four groups. Rats in the 1st and 2nd groups were treated with the extract in a same dose but with two different courses of therapy. Rats in the 3rd group were treated with celecoxib as a positive control where as the 4th group was treated with normal saline as a negative control. Evaluation of osteoarthritis changes was assessed with the aid of radiology, histopathology score and immunohistochemistry to explore immunoreactivity in the synovium. Assay of prostaglandins in the serum had been implemented to explore their role in osteoarthritis events and regulation. Gross and microscopic results revealed curative effects of the extract on the osteoarthritis accompanied with improved immunoreactivity of the synovium. Data showed significant hormonal changes in different treated groups, indicating their role in osteoarthritis. In conclusion, the extract showed inhibitory effect on joint degradation and its earlier therapeutic application reflects importance of earlier treatment on the disease progression. Immunoreactivity as well as serum prostaglandins concentrations could be used as good markers to evaluate osteoarthritis events in the affected joints.
F.J. Al-Saffar, S. Ganabadi and S. Fakuraz, 2011. Response of Channa striatus Extract Against Monosodium Iodoacetate Induced Osteoarthritis in Rats. Journal of Animal and Veterinary Advances, 10: 460-469.