Abstract: The recombinant virus with human H1N1 influenza virus HA, NA gene fragments and six gene fragments of the PR8 strain was successfully rescued and prepared in an recombinant (H1N1) influenza inactivated vaccine as an antigen. Researchers chose BALB/c mice as animal models to evaluate the vaccines immunity. The HI test results show that the vaccine can induce a high level HI antibody for human influenza A virus (H1N1) and swine influenza virus (H1N1) in mice. The HI antibody can be induced 1 week after immunization. Researchers monitored for 8 weeks after the second immunization and high antibody levels remained. The mouse challenge protection test showed that the vaccine can effectively protect the attack of the human influenza A (H1N1) and swine influenza virus (H1N1). It provides technical reserves for preventing a pandemic H1N1 influenza in the future in swine or other mammals.
Weixin Jia, Wenbao Qi, Lang Gong, Mingming Sun and Ming Liao, 2012. Construction and Immunogenicity Study of a Veterinary Recombinant Influenza A (H1N1) Inactivated Vaccine. Journal of Animal and Veterinary Advances, 11: 3213-3216.