Abstract: The purpose of this study was to evaluate the effect of the ethanol extract from the grain larvae (GLE: Grain Larvae Ethanol extract) on the blood lipid level of high-fat diet-induced obese rats (Experiment I) and on the protective effect of liver damage in rats that were given intraperitoneal injections of Chlorotetracycline (CCl₄) and alcohol (Experiment II). For Experiment I, 27 male rats (SDS strain) were randomized into three treatment groups: NC (Normal Control group fed with chow diet without the administration of GLE), HO (High-fat diet induced Obese group) and HOE (High-fat diet induced Obese rats administered orally with GLE 5.0 mg/100 g body weight). For Experiment II, 45 male rats (SDS strain) were randomized into five treatment groups: T1 (control group), T2 (intraperitoneal injection of CCl₄), T3 (oral administration of GLE combined with intraperitoneal injection of CCl₄), T4 (combined administration of GLE and alcohol) and T5 (intraperitoneal injection of alcohol combined with oral administration of GLE). Compared with HO, the levels of triglyceride, total cholesterol and LDL-cholesterol in blood decreased significantly in HOE while the HDL-cholesterol level showed a significant increase (p<0.05). Concentrations of AST, ALT, γ-GTP and bilirubin in blood significantly decreased in T3 and T5 groups with oral administration of GLE, compared with T2 and T4 groups (p<0.05). In rats in T3 and T5 groups, recovery of liver tissue cells from damage that had been induced by intraperitoneal injections of CCl₄ (T2) and alcohol (T4) could be observed.