Abstract: This study aimed to investigate the effect of human resource management on the performance with emphasize on the role of employee empowerment in Mellat Bank. The population of this study consists of all directors, employees and experts of Mellat Bank branches in Tehran. According to Krejcie and Morgan table, sample size was determined 226 people and sampling was done using simple random method. This study was conducted in a descriptive and correlational way and data collection was done by questionnaire. For assessing the human resource management, a questionnaire designed by Chen etc. was used and also for measuring organizational commitment, a questionnaire in accordance with Spears questionnaire (2000) and based on Likert scale was used. Validity of research tools was approved using experts and professionals consensus and the human resource management’s questionnaire reliability, employee empowerment and organizational performance using Cronbach’s alpha were confirmed as 0.812, 0.835 and 0.799, respectively. Data were analyzed with the use of structural equation models. The results show that the aspects of human resource management (training and development, compensation of services and performance evaluation of employees) have a significant effect on the organizational performance. However, sharing knowledge has no significant effect on organizational performance. Also, the result of moderator hypothesis shows that the variable of employee empowerment with impact factor of 0.209 significantly (and increasingly) adjusts the relationship between human resource management and organizational performance. As a result, mentioned hypothesis is confirmed.