Abstract: Tuberculosis bas been one of the leading causes of mortality in human community for many centuries. An important part in medical treatment of these patients is having confidence that all these patients should finish the period of their medical treatment. It bas been estimated that near 40% of these patients stop their medical treatment before finishing the period of their treatment. Due to increased emphasis on following medical treatment, we studied factors responsible for compliance of Medical treatment among complained and non-complained Tuberculosis patients referring to Urmia urban and non urban health centers in west Azarbaijan in Iran. This study was a descriptive research. Study participants were 82 Pulmonary Tuberculosis patients (50 female and 32 male) aged between 15-65 years old. The integrated Model of Health Behaviors was used to elicit information related to factors responsible for compliance of Medical treatment among complained and non-complained Tuberculosis patients. The questionnaire included 8 parts and consisted of 53 questions. Also, the questionnaire was based on the Integrated Model of Health Behaviors that evaluate socio-demographic and 5 components of (Knowledge, cues, health beliefs, self- efficacy and social support) in Tuberculosis patients. The data was analyzed by software of SPSS/Win. The Findings showed that the majority (63.04%) of complained and majority (58.33%) of non complained Tuberculosis patients were female. Findings showed that there was a significant differences between compliance of medical treatments and health beliefs and self- efficacy of Tuberculosis patients (p<0.001). On contrary, there was no significant differences between knowledge and socio-demographic characteristics and compliance of medical treatment. Results of this study revealed that complained patients had a good self-efficacy and health beliefs in compare with non complained Tuberculosis patients. According to the importance of compliance of medical treatment in Tuberculosis patients, the community health nurse in confronting with Tuberculosis patients should attend to their self efficacy, sensitivity to the disease, attitudes toward the disease, beliefs, obstacles for the medical treatment and also their awareness of the advantages of the medical treatment. ln the case of confronting with a patient who is susceptible for non compliance of medical treatment, the nurse could prepare the condition of compliance of treatment or involve him in DOTS program.