Authors : Hamzah Jasim Joudoh, Nada Farhan Kadhim and Amany Mohammed Al-Kaysi
Abstract: The present experiment aimed to determine the effect of gamma ray at doses of 11.883 μSv on splenic and liver tissue of albino male mice, at the different time of exposure (4, 8, 12, 16, 21, 24, 32 days). Irradiated mice were sacrificed after inhalator anesthesia, then tissue's samples of spleen and liver were taken from all experiment's animals for histopathological study, the results of pathology showed seriously changes within splenic tissues represented by depletion of white pulp more clearly after 12 days with proliferation of megakaryocyte with infiltration of inflammatory cells out of peripheral blood vessels, spleen, also, showed depletion of lymphoid follicles after 24 days post radiation and severe destruction of spleen parenchyma with congestive blood vessels in addition to deposition of amyloid-like substances were also, observable. These depositions of amyloid-like substances appear more clearly around lymphoid follicles after 32 days irradiation. Liver tissues at early exposed time (4, 8, 12, 16 days) showed degenerative changes as; Enlargement of hepatocytes with absence of sinusoids and increase in the number of kupffer cells with infiltration of inflammatory cells in a sinusoid, also, showed large necrotic area appear surrounded by the inflammatory zone. After 21, 24, 32 days livers tissues showed focal aggregation of inflammatory cells in many sections appears as focal granuloma.
Hamzah Jasim Joudoh, Nada Farhan Kadhim and Amany Mohammed Al-Kaysi, 2018. Study the Effect of Gamma Rays on the Spleen and Liver of Albino Male Mice. Research Journal of Biological Sciences, 13: 8-14.