Authors : Ana Martins , Isabel Couto , Lone Aagaard , Marta Martins , Miguel Viveiros Jette E Kristiansen and Leonard Amaral
Abstract: MRSA COL strain that is very susceptible to erythromycin (MIC < 0.4) and highly resistant to oxacillin (MIC 400 ug/ml) can be adapted to concentrations of oxacillin as high as 6400 ug/ml. During adaptation, it slowly becomes increasingly resistant to erythromycin (MIC >30 ug/ml after adaptation to 3200 ug/ml of oxacillin). The efflux pump inhibitor rifampin restores initial susceptibility to erythromycin.
Ana Martins , Isabel Couto , Lone Aagaard , Marta Martins , Miguel Viveiros Jette E Kristiansen and Leonard Amaral , 2007. Increasing Concentrations of Oxacillin Yield Efflux Pump Mediated Mdr Phenotype of Mrsa Col. Research Journal of Medical Sciences, 1: 13-15.