Authors : Omid Mashrabi , Mehdi Dolati Tapeh Rasht , Mohammad Reza Jafari Nakhjavani and Sima Abedi Azar
Abstract: Renal osteodystrophy is one of the most common potentially debilitating complications affecting patients with chronic renal failure. The most reliable markers of bone turnover are intact PTH,and bone alkaline phosphatase. The evaluation of bone mineral densitometry is a useful tool for the detection of hyperpara-thyroid bone disease. The aim of this study was the evaluation of effects of hemodialysis on metabolic bone disease in patients with chronic renal failure. A prospective and analytical study was performed to evaluate the bone disease in hemodialysis patients from 2004 to 2005 in hemodialysis ward of Emam Khomeini hospital of Tabriz medical university. Thirty hemodialysis (14 male) patients and 30 non- hemodialysis patients (13 male) with chronic renal failure (Glomerular Filtration Rate < 20 mL min 1) as control groups, were enruled the study. Bone mineral densitometry of vertebral spine and neck of femur were performed in all patients. X-ray was performed at knee and wrist in the all patients. Data analyzed by SPSS 11.5 software and T-test and Chi-Square test and the level of meaningfulness was considered as p< 0.05. The mean of alkaline phosphatase in hemodialysis patients was 301.53�250.10 mg dL 1 and in non-hemodialysis patients was 248.53�106.52 mg dL 1 (p = 0.290). The mean of intact parathyroid hormone in hemodialysis patients was 69.17�45.41 pg mL 1 and in non-hemodialysis patients was 66.64�46.94 pg mL 1 (p = 0.833). The mean of Z score of Spine in hemodialysis patients was -1.25�1.15 and in non-hemodialysis patients was 0.45�1.35. (p = 0.000). The mean of Z score of femur in hemodialysis patients was -0.45�1.54 and in non-hemodialysis patients was 1.2�1.01 (p = 0.000). This study showed a marked decrease in bone mineral density in a high number of dialysis patients. Z score was significantly lower in hemodialysis patients comparing non-hemodialysis patients. Bone mineral densitometry is useful method in evaluation of bone disease in hemodialysis patients.
Omid Mashrabi , Mehdi Dolati Tapeh Rasht , Mohammad Reza Jafari Nakhjavani and Sima Abedi Azar , 2007. Evaluation Bone Disease in Hemodialysis Patients. Research Journal of Medical Sciences, 1: 152-156.