Authors : L.A. Olayaki , M.S. Ajao , J. Ayo , M.T. Ayinla and A.O. Soladoye
Abstract: Women during menstrual cycle have demonstrated variability in cardiovascular responses, including flow mediated dilatation and calcium levels in cervical secretions. The experiment was designed to study the relationship between plasma calcium ions and some cardiovascular changes during the phases of menstrual cycle. Twenty young women aged 19-24 years with menstrual cycles that were regular and 27-30 days in length participated in the study. Venous blood sample was collected for plasma Ca2+ estimate using colometric method and callidy blue reagent and glycoetherdiamine as diluting agent. Systolic Blood Pressure (SBP) increased from 113.40±4.73 mmHg to 118.53±3.42 during the early follicular to the periovulatory phase. The difference is statistically significant (p< 0.05). There was no statistical difference in the level of Diastolic Blood Pressure (DBP) measured across the menstrual cycle. The Heart Rate (HR) increased from 74.40±5.03mmHg during the early follicular phase to 86.73±8.24 mmHg during the periovulatory phase and then reduced to 90.73±8.96 mmHg during the mid-luteal phase. Both the increase and subsequent decrease were statistically significant (p< 0.05). Plasma Ca2+ concentration peaked at periovulatory phase i.e. concentration of 9.85±0.41 mg dL 1 compare to 8.65±0.61 mg dL 1 during the early follicular phase (p< 0.005). and then fell to 9.25±0.75 mg dL 1 during the mid-luteal phase (p< 0.05). The result shows a positive relationship between systolic blood pressure and plasma Ca2+ in pre-menopausal women across the menstrual cycle with both of them peaking at periovulatory phase.
L.A. Olayaki , M.S. Ajao , J. Ayo , M.T. Ayinla and A.O. Soladoye , 2007. Plasma Calcium Ions and Some Cardiovascular Changes During Phases of Menstrual Cycle in Young Premenopausal Nigerian Women . Research Journal of Medical Sciences, 1: 267-270.