Abstract: A highway facility must, to varying degrees, serve three interests simultaneously, the road user, the abutting property owner and the general public. AIDS is not just a public health concern in the sub-Saharan Africa. The epidemic threatens to reverse decades of development. The more people travel the faster and further HIV can spread. Thus, population movement in the form of transportation usage is an important factor in the spread of AIDS. The purpose of this paper is to develop a conceptual framework for reducing the HIV/AIDS vulnerability of road users and their environment through a systems approach based on a transport sector�s unique attributes. It is anticipated that development planning and creative problem solving can also lead to new modes of cooperation within the transport sector, enabling economic survival in places most severely impacted by the HIV epidemic. The transport sector has unique potential to contribute to the reduction of HIV transmission. Many of the situations in which HIV spreads can be changed through strategies and policies relating to the transport sector. The study concludes that strategic planning can reduce the number of people infected and help ensure that everyone is prepared for challenges that will arise from widespread illness and death through assessing impacts and charting longer-term directions as the basis for shorter-term tactical and operational actions.