Abstract: This study investigated, the attitudes of females towards genital mutilation and the harmful effects in the lives of undergraduate females in a Nigerian University. The population consisted of all the undergraduate females in Nigeria. The sample of 200 females were purposively selected in various Departments in the Faculty of Education, University of Ado-Ekiti during the sandwich programme because people from various cultures and tribes were part of the programme. Simple random was used in selecting the sample. A questionnaire titled Female Mutilation Questionnaire (FMQ) was used to collect data for the study. The data were analyzed with the use of descriptive statistical techniques like frequency counts, percentages, t-test analysis of variance. The findings show that greater percentage of the female have negative attitude towards female genital mutilation and that there is a significant relationship between female circumcision and health of females as a result of the physical and psychological effects involved. It was therefore, recommended that government, health care provider and counsellors should organise seminars, conferences and workshop to educate the masses on the harmful effects of FGM. Voices should be raised, the time is right for communities to rise up and protest the practice of FGM without delay. Legal support for FGM could be reversed and abandoned if attitudes and custom are collectively addressed by the practicing communities with the involvement of religion and moral leaders working together to ban and penalize FGM.