Authors : Zhian M. Ibrahim Dezayee and Abdulqadir A. Alnakshabandi
Abstract: Changes in immunological parameters are observed in Type 1 (T1D) and Type 2 (T2D) diabetes. Some of them are linked with diabetic complications this study aimed to assess some components of complement system (notably C3 and C4) and immunoglobulins (IgA, IgG, IgM) in T1D and T2D in reference to their glycemic control. A total number of 160 (70 male and 90 female) T1D and 75 T2D (25 male and 50 female) patients who allocated randomly as well as 40 healthy subjects are enrolled in the study. Glycosylated hemoglobin (HbA1c%) and serum glucose, complements C3, C4 and immunoglobulins IgA, IgG and IgM were measured. On 4 out of 160 T1D patients have HbA1c >7% and none of T2D patients havely than HbA1c >11%. Serum C3 and C4 of T1D patients is significantly less than corresponding value of healthy subjects and the lowest value of C3 is observed in patients with HbA1c >11%. Only serum IgM is significantly decreased in T1D and T2D patients compared with healthy subjects and there is no significant differences between T1D and T2D patients. Some immunological parameters are depressed in poor-controlled diabetes. The difference in immune response between T1D and T2D patients is observed in serum C3.
Zhian M. Ibrahim Dezayee and Abdulqadir A. Alnakshabandi, 2011. Assessment of Some Immunological Parametrs in Respect to Glycemic Control in Type 1 and 2 Diabetes Mellitus: Comparative Study. Research Journal of Medical Sciences, 5: 119-121.