Authors : Ali Namvaran Abbas Abad, Mir Hadi Khayate Nouri and Farzaneh Tavakkoli
Abstract: Studies have shown that chamomile contains significant amounts of free amino acids and flavonoids that have anti-inflammatory, anti-seizure and anti fever effects. Vincristine-based chemotherapy is the major treatment of Hodgkin’s and non-Hodgkin’s lymphoma, nephroblastoma and acute lymphoblastic leukemia. Studies showed that vincristine has neuropathic effects in humans and different animal models. In this study, anticonvulsant effects of hydroalcoholic extract of Matricaria recutita and convulsant effects of vincristine using the standard method of chemical seizure caused by Pentylenetetrazole (PTZ) in mice was investigated. For this propose first group, received normal saline, group II received Matricaria recutita hydroalcoholic extract (200 mg kg-1) as intraperitoneal, vincristine group III received (10 μg/kg/day) intravenously for 10 days in the fourth group of Matricaria recutita hydroalcoholic extract plus vincristine was used and the subsequent seizure threshold was determined for each group. The results of this study showed that PTZ-induced seizure threshold in control mice was 35.52±0.87 mg kg-1 and chamomile hydroalcoholic extract significantly (p<0.05) increased the PTZ seizure threshold. Seizure threshold in the vincristine group significantly (p<0.05) decreased. Simultaneous uses of vincristine and Matricaria recutita extract caused to significantly increased seizure threshold (p<0.05) in vincristine taking group. The existence of several types of antioxidants and flavonoids in Matricaria recutita that have antioxidant effects in addition to anticonvulsant effects of this plant are set to reduce the neuropathic effects of vincristine. However, the anticonvulsant effect in human and material mechanisms involved need further investigations.
Ali Namvaran Abbas Abad, Mir Hadi Khayate Nouri and Farzaneh Tavakkoli, 2011. Study of Matricaria recutita and Vincristine Effects on PTZ-Induced Seizure Threshold in Mice. Research Journal of Medical Sciences, 5: 247-251.