Authors : Buavaroon Srichaikul, Supachai Samappito, Gordon Bakker, Weerasuk Seubsoh and Kittiphong Boonsong
Abstract: This study was carried out in Mahasarakham Primary Healthcare Centre, Mahasarakham province in the area of Northeastern of Thailand. The experiment was randomized control trial comparative clinical study in order to examine the efficacy of Areca catechu Linn. and Mebendazole in the treatment of antihelmintic activity of mixed worms infection in human. The experimental group consisted of 10 patients and 5 patients for control group with inclusion and exclusion criteria which were screened by the selection of mixed worm infection symptoms samples. The investigation and extraction of worm Eggs Per Gram of patient feces method (EPG) were performed with Ether Formalin Sedimentation test. The percentage of reduction of Eggs Per Gram (EPG) of patient feces were collected, counted and confirmed by parasitologist and the clinical efficacy was investigated by the physician and the pharmacist. The % EPG data were collected before and after the treatment with Areca catechu Linn. and with placebo. The result showed and confirmed by Wilcoxon Signed Ranks test and also confirmed Kruskal Wallis Method which showed that Mebendazole had higher in antihelmintic activity than Areca catechu Linn. The efficacy in antihelmintic activity in % reduction of worm eggs per gram (in patient feces) by Mebendazole treatment was 87.50 and % reduction of eggs per gram by Areca catechu Linn. was 68.12%. The suggestion of this study should increase the number of samples of worm infected patients which the samples can be identified with the specification helminthes genus and species in order to obtain more accurate by the treatment Areca catechu Linn. and Mebendazole. The future study can be carried out in various dosage forms in order to obtain the maximum efficacy in pharmacokinetic and pharmacological activity.
Buavaroon Srichaikul, Supachai Samappito, Gordon Bakker, Weerasuk Seubsoh and Kittiphong Boonsong, 2012. Comparative Double Blind Trial in Antihelmintic Efficacy Between Mebendazole and Areca catechu L.. Research Journal of Medical Sciences, 6: 124-128.