Authors : Lawal Olukayode Adeayo and A.O. Adedire
Abstract: Malaria is one of the prevalent infections with high mortality in >90 countries in the world and it is associated with the coagulation cascade and fibrinolytic activities. The study investigated fibrinolytic activities in individuals with malaria infection at the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, South-Western Nigeria. Seventy samples were collected, fifty from malaria patients and twenty from healthy individuals which were used as control. Plasma samples were obtained from the subjects and these were used to investigate the fibrinolytic activities using the euglobulin clot lysis time and fibrinogen concentration methods. It was discovered that all the fifty malaria positive samples had a prolonged euglobulin clot lysis time with 395.54±50.20 indicating hypofibrinolysis and these eventually had high fibrinogen concentration in comparison with the control samples which had normal euglobulin lysis time with 138.85±18.37. The values were significantly different when both test and control samples were compared (p<0.05). There was also high fibrinogen concentration of 297.94±24.23 when compared with the control that had 159.30±7.34 which is also significantly different (p<0.05). Malaria infection had been seen as contributing to thromboembolic process in any infected individual. The results necessitate the need for scrupulous prevention and prompt treatment of malaria in infected patients.
Lawal Olukayode Adeayo and A.O. Adedire, 2012. Fibrinolytic Activities in Malaria Patients at the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria. Research Journal of Medical Sciences, 6: 134-137.