Authors : Kamal Mansi, Maryam Abu-Albasal and Talal Aburjia
Abstract: Hepatoprotective effect of methanolic extracts from Artemisia sieberi Besser aerial parts was investigated against ethanol induced-acute hepatotoxicity in experimental rats. They were divided into four groups with 20 rats in each one. Group I: non-hepatotoxic rats received only the vehicle (0.5 mLkg-1 body weight) and served as a control group. Group II: rats were orally administered with 2 mL ethanol every alternate day for 30 days to generate hepatotoxity. Groups III: hepatotoxic rats treated with 25 mgkg-1 silymarin drug. Group IV: hepatotoxic rats treated with 100 mgkg-1 methanol extracts of Artemisia sieberi Besser. All treatments were orally administrated by gavage for 30 consecutive days. At the end of the experiment, the rats of all groups were sacrificed and the excised liver was weighed. Liver enzyme markers (SGOT, SGPT, ALP), total protein, albumin, bilirubin (direct and total) and lipid profile were measured from blood serum samples. As well, the analysis of the CBC was performed on whole blood samples. Results revealed significant increase of the liver enzyme markers, total and direct bilirubin and lipid profile in the hepatotoxic group. Conversely, significant reduction in the liver weight, levels of total protein, albumin and parameters of the CBC panel was also noticed as compared with the control group. However, treatment with methanol extracts significantly enhanced the liver weight and brought back the altered levels of hematological and biochemical markers to the nearby normal levels, compared to those detected in the control and silymarin treated groups. It is concluded from the results of the present study that the methanol extracts of Artemisia sieberi Besser aerial parts possesses hepatoprotective activity against ethanol induced hepatotoxicity in rats.
Kamal Mansi, Maryam Abu-Albasal and Talal Aburjia, 2019. Hepatoprotective Activity of Methanol Extracts from Artemisia Sieberi Besser (A. Herba-alba) Against Ethanol Induced Hepatic Damage Rats. Research Journal of Medical Sciences, 13: 102-108.