Abstract: Binary vulgaris is a very common disease among adolescents. Due to the effects it has on people's faces, it can impose many social and psychological costs on patients, so the treatment of this disease in addition to a health need is a social necessity. It is psychological. Therefore, in this study, Adapalene 0.1% and benzoyl peroxide 2.5% in a gel formulation were formulated for the first time in IRAN to guarantee better results and increase patients' acceptance of these two drugs at the same time. In the first stage, several formulations will be prepared using various jellies, which contain both benzoyl peroxide and adapalene, as well as other compounds such as hemoquantum, protective, etc. In the second stage, the various formulations prepared will be tested for physicochemical control. Control tests include determining the amount of active ingredient, checking for release simultaneously with the manufacture of the products, accelerated stability tests will be performed on the formulation to select the desired formulation based on the results of the control tests. In this work, we made eighty formulations, of which three formulations had the best physical and functional stability. Among them, la formulation was determined as the superior formulation and various physicochemical and microbial tests were performed on this formulation, all of which will confirm the superior product production method.