Authors : B.U. Wakayo, P.S. Brar, S. Prabhakar and A.K. Arora
Abstract: A field trial was conducted to evaluate immunomodulatory prophylactic modalities against persistent uterine infection in 24 Murrah buffaloes and 21 cross-bred Holstein Frisian cows. All animals were treated with intramuscular ceftiofur sodium for 5 days post-calving. On or after 7th day animals were randomly assigned to either; intrauterine normal saline (controls = 15), intrauterine E. coli LPS (LPS = 15) or intramuscular Cloprostenol (cloprostenol = 15). Endometritis was Determined at 35 days in Milk (DIM) and estrus, breeding and conception were monitored until 120 DIM. Clinical Endometritis (CE) occurred in 6 (60%), 3 (30%) and 2 (20%) assisted calving animals assigned to control, cloprostenol and LPS groups, respectively (p = 0.196). All but one assisted calving animals had cytological uterine inflammation at 35 DIM. Among normal calving animals 1 (20%), 3 (60%) and 4 (80%) of those in control, LPS and cloprostenol groups, respectively showed cytological uterine inflammation (p = 0.415). Meanwhile, 93.3, 86.7 and 66.7% of the LPS, Cloprostenol and Control group animals were observed in heat within 120 DIM (p = 0.229). Rate of conception within 120 DIM was similar 3 (37.5) among treatment groups in buffaloes but varied in cows from a high of 3 (42.9) in control group to a low of 0 in Cloprostenol group. The application of early puerperal immunostimulatory treatment with cloprotenol or E. coli LPS for prevention of endometritis and sub-fertility appears limited requires further validation.
B.U. Wakayo, P.S. Brar, S. Prabhakar and A.K. Arora, 2014. Evaluation of Prophylactic Cloprostenol and E. coli LPS Treatment Against Endometritis in Dairy Cows and Buffaloes. Research Journal of Animal Sciences, 8: 24-29.