Authors : Soontaree Petchdee, Nakrob Pattanapon, Ratikorn Bootcha, Petcharin Srivattanakul and Taweesak Songserm
Abstract: Coronary artery disease is a common precursor to sudden cardiac death worldwide. Advanced symptoms usually include Myocardial Infarction (MI) due to atherosclerosis of coronary arteries. To repair or regenerate lost myocardium and coronary vasculature, stem cell transplantation is a promising therapeutic approach for the treatment of coronary heart diseases. In this study, the therapeutic effects of multipotent Stem Cells from Human Exfoliated Deciduous teeth (SHED) were examined. The 30 adult male New Zealand White rabbits underwent a left thoracotomy approach for producing chronic infarcted heart. The marginal branch of the left circumflex coronary artery was ligated over 8 weeks to produce an ischemic area of 20-25% of the Left Ventricle (LV). SHEDs were freshly prepared and 1.0 mL of 106 cells were injected to each of eight rabbits via the marginal ear vein. Echocardiography and Heart Rate Variability (HRV) were measured to reflect cardiac function. The infarcted size measurements were performed at the end of each experiment. The SHED treatment groups show significant improvement in cardiac autonomic tone and reduction in infarcted size. Dental tissue derived stem cell transplantation confirmed a restoration of the heart. The results suggest that SHED could provide an alternative selection of the precursor cells for cardiac repair.
Soontaree Petchdee, Nakrob Pattanapon, Ratikorn Bootcha, Petcharin Srivattanakul and Taweesak Songserm, 2014. Dental Tissue-Derived Stem Cells Exerts Therapeutic Effects on Chronic Myocardial Infarction Model of Rabbit. The Cardiology, 9: 1-6.