Abstract: The chemical constituent of the leaves of Aspilia africana were studied. The results shows the following chemical constituents; alkoloids (6.350±0.841%), tannins (0.188±0.035%), saponins (2.260±0.15%) flavonoids (2.006±-0.11%) and phenols (0.109±0.15%), respectively. The concentration per 100 g of vitamins in the leaf of the plant are as follows ascorbic acid (11.00±0.15 mg) niacin (3.045±0.081 mg) thiamine (1.940±0.025 mg), riboflavin (0.135±0.100 mg). The mineral elements determined are per 100 g Calcium (246±4.345 mg), Nitrogen (213.00±6.600) and Phosphorus (25.00±0.500), zinc (34.675±0.54), nickel (10.975±1.330), Selenium (Se) (10.875±1.880), Boron (B) (9.675±2.045) and lead (Pb) (7.425±1.050), these results show that the list may possess the medicinal potentials as claimed by tradomedical practitioners.