References

Aigner, B., K. Pambalk, U. Reichart, U. Besenfelder, Z. Bosze and M. Renner, 1999. Species-specific alternative splicing of transgenic RNA in the mammary glands of pigs, rabbits and mice. Biochem. Biophys. Res. Commun., 257: 843-850.
PubMed  |  

Aigner, B., U. Besenfelder, J. Seregi, L.V. Frenyo, T. Sahin-Toth and G. Brem, 1996. Expression of the murine wild-type tyrosinase gene in transgenic rabbits. Transgenic Res., 5: 405-411.
PubMed  |  

Andersen, D.C. and L. Krummen, 2002. Recombinant protein expression for therapeutic applications. Curr. Opin. Biotechnol., 13: 117-123.
PubMed  |  

Baranyi, M., G. Brignon, P. Anglade and B. Ribadeau-Dumas, 1995. New data on the proteins of rabbit (Oryctolagus cuniculus) milk. Comp. Biochem. Physiol. B Biochem. Mol. Biol., 111: 407-415.
PubMed  |  

Barbagallo, C.M., J. Fan, P.J. Blanche, M. Rizzo, J.M. Taylor and R.M. Krauss, 1999. Overexpression of human hepatic lipase and ApoE in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass distributions. Arterioscler. Thromb. Vasc. Biol., 19: 625-632.
PubMed  |  

Besenfelder, U., B. Aigner, M. Muller and G. Brem, 1998. Generation and Application of Transgenic Rabbits. In: Microinjection and Transgenesis, Cid-Arregui, A. and A. Garcia-Carranca (Eds.). Springer-Verlag, New York, pp: 561-586.

Bodrogi, L., R. Brands, W. Raaben, W. Seinen, M. Baranyi and D. Fiechter, 2006. High level expression of tissue-nonspecific alkaline phosphatase in the milk of transgenic rabbits. Transgenic Res., 15: 627-636.
Direct Link  |  

Bosze, Z., L. Hiripi, J.W. Carnwath and H. Niemann, 2003. The transgenic rabbit as model for human diseases and as a source of biologically active recombinant proteins. Transgenic Res., 12: 541-553.
CrossRef  |  PubMed  |  

Boulanger, L., S. Mallet, P. Chesne, P. Chrenek, C. Viglietta and L.M. Houdebine, 2002. Advantages and limits of using ubiquitous expressed EF1 alpha promoter for transgenesis in vivo and in vitro in rabbit. Transgenic Res., 11: 88-88.

Brem, G., U. Besenfelder, B. Aigner, M. Muller, I. Liebl and G. Schutz, 1996. YAC transgenesis in farm animals: Rescue of albinism in rabbits. Mol. Reprod. Dev., 44: 56-62.
PubMed  |  

Challah-Jacques, M., P. Chesne and J.P. Renard, 2003. Production of cloned rabbits by somatic nuclear transfer. Cloning Stem Cells, 5: 295-299.
PubMed  |  

Chapman, M.J., 1980. Animal lipoproteins: Chemistry, structure and comparative aspects. J. Lipid Res., 21: 789-853.
PubMed  |  

Chesne, P., P.G. Adenot, C. Vigilietta, M. Baratt, L. Boulanger and J. Renard, 2002. Cloned rabbits produced by nuclear transfer from adult somatic cells. Nat. Biotech., 20: 366-369.
CrossRef  |  PubMed  |  

Chrenek, P., D. Vasicek, V. Alexander, Makarevich and R. Jurcik et al., 2005. Increased transgene integration efficiency upon microinjection of DNA into both pronuclei of rabbit embryos. Transgenic Res., 14: 417-442.
CrossRef  |  

Chrenek, P., L. Ryban, H. Vetr, A.V. Makarevich, P. Uhrin, R.K. Paleyanda and B.R. Binder, 2007. Expression of recombinant human factor VIII in milk of several generations of transgenic rabbits. Transgenic. Res., 16: 353-361.
CrossRef  |  

Clark, A.J., 1998. Gene expression in the mammary glands of transgenic animals. Biochem. Soc. Symp., 63: 133-140.
PubMed  |  

Collas, P. and J.M. Robl, 1990. Factors affecting the efficiency of nuclear transplantation in the rabbit embryo. Biol. Reprod., 43: 877-884.
PubMed  |  

Duby, R.T., M.B. Cuniff, J.M. Belak, J.J. Balise and J.M. Robl, 1993. Effect of milking frequency on collection of milk from nursing New Zealand white rabbits. Anim. Biotechnol., 4: 31-42.
CrossRef  |  

Duff, G.L., 1935. Experimental cholesterol arteriosclerosis and its relationship to human arteriosclerosis. Arch. Pathol., 20: 81-123.

Emmanuel, F.J., M. Caillaud, N. Hennuyer, C. Fievet, I. Viry and L.M. Houdebine, 1996. Overexpression of human alipoprotein A-I inhibits atherosclerosis development in Watanabe rabbits. Circulation, 94: 10-632.

Fan, J. and T. Watanabe, 2000. Cholesterol-fed and transgenic rabbit models for the study of atherosclerosis. J. Atheroscler. Thromb., 7: 26-32.
Direct Link  |  

Fan, J., H. Sun, H, Unoki, M. Shiomi and T. Watanabe, 2001. Enhanced atherosclerosis in Lp(a) WHHL transgenic rabbits. Ann. NY Acad. Sci., 947: 362-365.
PubMed  |  

Fan, J., J. Wang, A. Bensadoun, S.J. Lauer, Q. Dang, R.W. Mahley and J.M. Taylor, 1994. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc. Natl. Acad. Sci. USA., 91: 8724-8728.
Direct Link  |  

Fan, J., M. Challah, H. Shimoyamada and T. Watanabe, 2000. Transgenic rabbits expressing human apolipoprotein(a) as a useful model for the study of lipoprotein(a). Ann. NY Acad. Sci., 902: 347-351.
CrossRef  |  

Franz, W.M., O.J. Mueller, M. Fleischmann, P. Babij, N. Frey and M. Mueller, 1999. The 2.3 kb smooth muscle myosin heavy chain promoter directs gene expression into the vascular system of transgenic mice and rabbits. Cardiovasc Res., 43: 1040-1048.
PubMed  |  

Garber, K., 2000. rFactor VIII deficit questioned. Nat. Biotechnol., 18: 1133-1133.
CrossRef  |  

Giraldo, J.L., A. Habana and A.J. Duleba, 2000. Septate uterus associated with cervical duplication and vaginal septum. J. Am. Assoc. Gynecol Laparosc, 7: 277-279.
CrossRef  |  

Glass, C.K. and J.L. Witztum, 2001. Atherosclerosis: The road ahead. Cell, 104: 503-516.
PubMed  |  Direct Link  |  

Gordon, J.W. and F.H. Ruddle, 1981. Mammalian gonadal determination and gametogenesis. Sci., 4488: 1265-1271.
PubMed  |  

Hadlaczky, G., 2001. Satellite DNA-based artificial chromosomes for use in gene therapy. Curr. Opin. Mol. Ther., 3: 125-132.
PubMed  |  

Hirabayashi, M., M. Hirao, R. Takahashi, K. Kimura, K. Hirasawa and M. Ueda, 2000. Production of transgenic rabbits using centrifuged pronuclear zygotes. J. Vet. Med. Sci., 62: 1047-1052.
PubMed  |  

Hiripi, L., F. Makovics, R. Halter, M. Baranyi, D. Paul and J.W. Carnwath, 2003. Expression of active human blood clotting factor VIII in the mammary gland of transgenic rabbits. DNA and Cell Biol., 22: 41-45.
CrossRef  |  

Hoeg, J.M., S. Santamarina-Fojo, A.M. Berard, J.F. Cornhill and E.E. Herderick et al., 1996. Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis. Proc. Natl. Acad. Sci. USA., 93: 11448-11453.
PubMed  |  

James, J. and J. Robbins, 1997. Molecular remodeling of cardiac contractile function. Am. J. Physiol., 273: H2105-H2118.
PubMed  |  Direct Link  |  

James, J., A. Sanbe, K. Yager, L. Martin, R. Klevitsky and J. Robbins, 2000. Genetic manipulation of the rabbit heart via transgenesis. Circulation, 101: 1715-1721.
PubMed  |  Direct Link  |  

James, J., L. Martin, M. Krenz , C. Quatman and F. Jones et al., 2005. Forced expression of alpha-myosin heavy chain in the rabbit ventricle results in cardioprotection under cardiomyopathic conditions. Circulation, 111: 2339-2346.
CrossRef  |  PubMed  |  Direct Link  |  

Kass, D.A., J.M. Hare and D. Georgakopoulos, 1998. Murine cardiac function: A cautionary tail. Circ. Res., 82: 519-522.
PubMed  |  Direct Link  |  

Kazazian, H.H., E.G.D. Tuddenham and S. Antonarakis, 1995. Haemophilia A and parahaemophilia: Deficiencies of Factor VIII and V. In: Medical and Metabolic Basis of Inherited Disease, Scriver, C., A. Beaudet, W. Sly and E. Valle (Eds.). McGraw-Hill, New York, pp: 3241-3268.

Kondo, M., T. Sakai, K. Komeima, Y. Kurimoto and H. Terasaki1 et al., 2008. Generation of a transgenic rabbit model of retinal degeneration. Invest. Ophth. Vis. Sci., 1: 2863-2871.
CrossRef  |  

Krylov, V., T. Tlapakova, J. Macha, J. Curlej, L. Ryban and P. Chrenek, 2008. Localization of human coagulation factor VIII (hFVIII) in transgenic rabbit by FISH-TSA: Identification of transgene copy numbet and transmission to next generation. Folia Biol., 54: 121-124.
PubMed  |  

Kubota, C., H. Yamakuchi, J. Todoroki, K. Mizoshita, N. Tabara, M. Barber and X. Yang, 2000. Six cloned calves produced from adult fibroblast cells after long-term culture. Proc. Natl. Acad. Sci. USA., 97: 990-995.
Direct Link  |  

Kupriyanov, S., K. Zeh and H. Baribault, 1998. Double pronuclei injection of DNA into zygotes increase yields of transgenic mouse lines. Transgenic Res., 7: 223-226.
PubMed  |  

La Ville, A., P.R. Turner, R.M. Pittilo, S. Martini, C.B. Marenah and P.M. Rowles, 1987. Hereditary hyperlipidemia in the rabbit due to overproduction of lipoproteins. I. Biochemical studies. Arteriosclerosis, 7: 105-112.
PubMed  |  

Larrick, J.W. and D.W. Thomas, 2001. Producing proteins in transgenic plants and animals. Curr. Opin. Biotechnol., 12: 411-418.
PubMed  |  

Lavitrano, M., A. Camaioni, V.M. Fazio, S. Dolci, M.G. Farace and C. Spadafora, 1989. Sperm cells as vectors for introducing foreign DNA into eggs: Genetic transformation of mice. Cell, 57: 717-723.
PubMed  |  Direct Link  |  

Lavitrano, M., M. Busnelli, M.G. Cerrito, R. Giovannoni, S. Manzini and A. Vargiolu, 2006. Sperm-mediated gene transfer. Reprod. Fertil. Dev., 18: 19-23.
Direct Link  |  

Lee, B.C., M.K. Kim, G. Jang, H.J. Oh and F. Yuda et al., 2005. Dogs cloned from adult somatic cells. Nature, 436: 641-641.
CrossRef  |  PubMed  |  Direct Link  |  

Li, L., W. Shen, L. Min, H. Dong, Y. Sun and Q. Pan, 2006. Human lactoferrin transgenic rabbits produced efficiently using dimethylsulfoxide-sperm-mediated gene transfer. Reprod. Fertil Dev., 18: 689-695.
PubMed  |  

Libby, P., 2002. Inflammation in atherosclerosis. Nature, 420: 868-874.
CrossRef  |  PubMed  |  Direct Link  |  

Maher, V.M. and B.G. Brown, 1995. Lipoprotein (a) and coronary heart disease. Curr. Opin. Lipidol., 6: 229-235.
Direct Link  |  

Marian, A.J., D.S. Wu Y Lim, M. McCluggage, K. Youker and Q.T. Yu, 1999. A transgenic rabbit model for human hypertrophic cardiomyopathy. J. Clin. Invest., 104: 1683-1692.
CrossRef  |  

Massoud, M., R. Bischoff, W. Dalemans, H. Pointu and L.M. Houdebin et al., 1991. Expression of active recombinant human alpha 1-antitrypsin in transgenic rabbits. J. Biotechnol., 18: 193-203.
CrossRef  |  

McLeod, R.S., A.M. LeBlanc, M.A. Langille, P.L. Mitchell and D.L. Currie, 2004. Conjugated linoleic acids, atherosclerosis and hepatic very-low-density lipoprotein metabolism. Am. J. Clin. Nutr., 79: 1169-1174.
Direct Link  |  

Molowa, D.T. and R. Mazanet, 2003. The state of biopharmaceutical manufacturing. Biotechnol. Annu. Rev., 9: 285-302.
CrossRef  |  

Montoliu, L., 2002. Gene transfer strategies in animal transgenesis. Cloning Stem. Cells, 4: 39-46.
CrossRef  |  Direct Link  |  

Nagueh, S.F., H.A. Kopelen, D.S. Lim, W.A. Zoghbi, M.A. Quinones and R. Roberts, 2000. Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation, 102: 1346-1350.
Direct Link  |  

Niemann, H., R. Halter, J.W. Carnwath, D. Herrmann, E. Lemme and D. Paul, 1999. Expression of human blood clotting factor VIII in the mammary gland of transgenic sheep. Transgenic Res., 8: 237-247.
CrossRef  |  

Nishizawa, T., Y. Ishikawa, J. Sadoshima, D.E. Vatner and S.F. Vatner et al., 2007. Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha. Am. J. Physiol. Heart. Circ. Physiol., 292: 971-976.
Direct Link  |  

Omar, B.A., S.C. Flores and J.M. McCord, 1992. Superoxide dismutase: Pharmacological developments and applications. Adv. Pharmacol., 23: 109-161.
CrossRef  |  

Overturf, M.L. and D.S. Loose-Mitchell, 1992. In vivo model systems: The choice of the experimental animal model for analysis of lipoproteins and atherosclerosis. Curr. Opin. Lipidol., 3: 179-185.
Direct Link  |  

Page, R.L., S.P. Bulter, A. Subramanian, F.C. Gwazdauskas, J.L. Johnson and W.H. Velander, 1995. Transgenesis in mice by cytoplasmic injection of polylysine/DNA mixtures. Transgenic Res., 4: 353-360.
CrossRef  |  

Paigen, B., B.Y. Ishida, J. Verstuyft, R.B. Winters and D. Albee, 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis, 10: 316-323.
Direct Link  |  

Paleyanda, R.K., W.H. Velander, T.K. Lee, D.H. Scandella, F.C. Gwazdauskas and J.W. Knight, 1997. Transgenic pigs produce functional human factor VIII in milk. Nat. Biotechnol., 15: 971-975.
CrossRef  |  

Palomares, L.A., S. Estrada-Mondaca and O.T. Ramirez, 2004. Production of recombinant proteins: Challenges and solutions. Methods Mol. Biol., 267: 15-52.
CrossRef  |  

Pattison, J.S., R.J. Waggoner, J. James, L. Martin and J. Gulick et al., 2008. Phospholamban overexpression in transgenic rabbits. Transgenic Res., 17: 157-170.
CrossRef  |  PubMed  |  Direct Link  |  

Pursel, V.G., R.J. Wall, D.J. Bolt, R.J. Palmiter and K.M. Ebert et al., 1985. Production of transgenic rabbits, sheep and pigs by microinjection. Nature, 315: 680-683.
CrossRef  |  

Raju, T.S., J.B. Briggs, S.M. Borge and A.J. Jones, 2000. Species-specific variation in glycosylation of IgG: evidence for the speciesspecific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics. Glycobiology, 10: 477-486.

Rodriguez, A., F.O. Castro, A. Aguilar, B. Ramos, D.G. Del Barco and R. Lleonart, 1995. Expression of active human erythropoietin in the mammary gland of lactating transgenic mice and rabbits. Biol. Res., 28: 141-153.
PubMed  |  

Ross, R., 1993. The pathogenesis of atherosclerosis: A perspective of the 1990s. Nature, 362: 801-809.
PubMed  |  

Rouy, D., N. Duverger, S.D. Lin, F. Emmanuel, L.M. Houdebine and P. Denefle, 1998. Apolipoprotein(a) yeast artificial chromosome transgenic rabbits. Lipoprotein(a) assembly with human and rabbit apolipoprotein B. J. Biol. Chem., 273: 1247-1251.
PubMed  |  

Sanbe, A., J. James, V. Tuzcu, S. Nas and L. Martin et al., 2005. A transgenic rabbit model for human troponin i-based hypertrophic. Bakken Res., 111: 2330-2338.
CrossRef  |  

Schiaffino, S. and C. Reggiani, 1996. Molecular diversity of myofibrillar proteins: Gene regulation and functional significance. Physiol., 76: 371-423.
Direct Link  |  

Seo, B.B., C.H. Kim, K. Yamanouchi, M. Takahashi, T. Sawasaki and C. Tachi, 2000. Co-injection of restriction enzyme427 with foreign DNA into the pronucleus for elevating production efficiencies of transgenic animals. Anim. Reprod. Sci., 3: 113-122.

Shen, W., L. Li, Q. Pan, L. Min, H. Dong and J. Deng, 2006. Efficient and simple production of transgenic mice and rabbits using the new DMSO-sperm mediated exogenous DNA transfer method. Mol. Reprod. Dev., 73: 589-594.
CrossRef  |  

Shimizu, T.N., K. Kai, Y. Morimoto, M. Ishihara, H. Oishi, M. Kikuchi and H. Arai, 2009. Simple rabbit model of vulnerable atherosclerotic plaque. Neurologia Medico-Chirurgica, 49: 327-332.
CrossRef  |  

Simmons, C. and D.G. Yansura, 1996. Translational level is a critical factor for the secretion of heterologous proteins in Escherichia coli. Nat. Biotechnol., 14: 629-634.
CrossRef  |  

Simth, K. and C. Spadafora, 2005. Sperm-mediated gene transfer: Applications and implications. Bio. Essays, 27: 251-262.
CrossRef  |  Direct Link  |  

Soler, E., A.L. Saux, F. Guinut, B. Passet and R. Cohen et al., 2005. Production of two vaccinating recombinant rotavirus proteins in the milk of transgenic rabbits. Transgenic Res., 14: 833-844.
CrossRef  |  

Soler, E., N. Parez, B. Passet, C. Dubuquoy and S. Riffault et al., 2007. Recombinant rotavirus inner core proteins produced in the milk of transgenic rabbits confer a high level of protection after intrarectal delivery. Vaccine, 25: 6373-6380.
CrossRef  |  

Spieker-Polet, H., P. Sethupathi, P.C. Yam and K.L. Knight, 1995. Rabbit monoclonal antibodies: Generating a fusion partner to produce rabbit-rabbit hybridomas. Proc. Natl. Acad. Sci. USA., 92: 9348-9352.
PubMed  |  

Stice, S.L. and J.M. Robl, 1988. Nuclear reprogramming in nuclear transplant rabbit embryos. Biol. Reprod., 39: 657-664.
PubMed  |  

Stromqvist, M., L.M. Houdebine, J.O. Andersson, A. Edlund and T. Johansson et al., 1997. Recombinant human extracellular superoxide dismutase produced in milk of transgenic rabbits. Transgenic Res., 6: 271-278.
CrossRef  |  

Tall, A.R., 1993. Plasma cholesteryl ester transfer protein. J. Lipid. Res., 34: 1255-1274.
PubMed  |  

Tjwa, M., P. Carmeliet and L. Moons, 2006. Novel transgenic rabbit model sheds light on the puzzling role of matrix metalloproteinase-12 in atherosclerosis. Circulation, 113: 1929-1932.
Direct Link  |  

Utermann, G., F. Hoppichler, H. Dieplinger, M. Seed, G. Thompson and E. Boerwinkle, 1989. Defects in the low density lipoprotein receptor gene affect lipoprotein (a) levels: Multiplicative interaction of two gene loci associated with premature atherosclerosis. Proc. Natl. Acad. Sci. USA., 86: 4171-4174.
PubMed  |  

Van Haeringen, W.A., M. den Bieman, G.F. Gillissen, A.E. Lankhorst, M.T. Kuiper, L.F. van Zutphen and H.A. van Lith, 2001. Mapping of a QTL for serum HDL cholesterol in the rabbit using AFLP technology. J. Hered., 92: 322-326.
CrossRef  |  

Van den Hout, H., A.J. Reuser, A.G. Vulto, M.C. Loonen, A. Cromme-Dijkhuis and A.T. Van der Ploeg, 2000. Recombinant human alpha-glucosidase from rabbit milk in Pompe patients. Lancet, 356: 397-398.
PubMed  |  

Van den Hout, J.M., A.J. Reuser, J.B. de Klerk, W.F. Arts, J.A. Smeitink and A.T. van der Ploeg, 2001. Enzyme therapy for Pompe disease with recombinant human alpha-glucosidase from rabbit milk. J. Inherit. Metabiol. Dis., 24: 266-274.
PubMed  |  

Vasicek, D., K. Vasickova, V. Parkanyi, J. Rafay and L. Ondruska, 2007. Effective generation of genetically modified rabbites bysperm medlated gene transfer. Word Rbbit. Sci., 15: 161-166.
Direct Link  |  

Wall, R.J., 1996. Transgenic livestock: Progress and prospects for the future. Theriogenology, 45: 57-68.
Direct Link  |  

Wang, H.J., A.X. Lin and Y.F. Chen, 2003. Association of rabbit sperm cells with exogenous DNA. Anim. Biotechnol., 14: 155-165.
CrossRef  |  

Watanabe, Y., 1980. Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit). Atherosclerosis, 36: 261-268.
PubMed  |  

Weidle, U.H., H. Lenz and G. Brem, 1991. Genes encoding a mouse monoclonal antibody are expressed in transgenic mice, rabbits and pigs. Gene, 98: 185-191.
CrossRef  |  

Werner, R.G., W. Noe, K. Kopp and M. Schluter, 1998. Appropriate mammalian expression systems for biopharmaceuticals. Arzneimittelforschung, 48: 870-880.
PubMed  |  

Wolf, E., P.M. Jehle, M.M. Weber, H. Sauerwein and A. Daxenberger et al., 1997. Human insulin-like growth factor I (IGF-I) produced in the mammary glands of transgenic rabbits: Yield, receptor binding, mitogenic activity and effects on IGF-binding proteins. Endocrinology, 138: 307-313.
PubMed  |  

Woods, G.L., K.L. White, D.K. Vanderwall, G.P. Li and K.I. Aston et al., 2003. A mule cloned from fetal cells by nuclear transfer. Science, 301: 1063-1063.
PubMed  |  

Yang, X., 1991. Embryo cloning by nuclear transfer in cattle and rabbits. Embryo Trans. News, 9: 10-22.

Zhang, X.J., D.L. Chinkes, A. Aarsland, D.N. Herndon and R.R. Wolfe, 2008. Lipid metabolism in diet-induced obese rabbits is similar to that of obese humans. J. Nutr. Mar., 138: 515-518.
PubMed  |  

Zhang, Z., J. Machac, G. Helft, S.G. Worthley and C. Tang et al., 2007. Non-invasive imaging of atherosclerotic plaque macrophage in a rabbit model with F-18 FDG PET: A histopathological correlation. BMC Nucl. Med., 6: 3-3.
CrossRef  |  

Zhou, Q., J.P. Renard, G. le Friec, V. Brochard and N. Beaujean et al., 2003. Generation of fertile cloned rats by regulating oocyte activation. Science, 302: 1179-1179.
PubMed  |  

Zinovieva, N., C. Lassnig, D. Schams, U. Besenfelder and E. Wolf et al., 1998. Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations. Transgenic Res., 7: 437-447.
CrossRef  |