Abstract: Four groups of adult male Sprague Dawley rats each consist of ten animals. All animals were experimentally wounded in the posterior neck area. Normal saline was applied topically to wounds of Group 1 as a negative control and pure un-boiled honey was applied topically to wounds of Group 2 animals. Wounds of Group 3 rats were treated with honey in combined with Chromolaena odorata aqueous leave extract. Group 4 rats act as positive control and treated with solcoseryl - Jelly. The effects of vehicles on the rate of wound healing and rate of infections were assessed. Wounds treated with honey alone or honey in combination with plant extracts and solcoseryl –Jelly showed clean and remain sterile and significantly healed earlier and much faster as compared to wounds treated with normal saline (Group 1). Wounds treated with solcosery – Jelly or honey in combination with plant extract also showed significantly earlier healing than honey alone There were no significant differences in wound healing rate between plant extract and solcoseryl - Jelly. This was indicated by improve rates of contraction and a decreased period of epithelialization and result in minimal scar formation. These results strongly document the beneficial effects of honey in combined with this extract for the acceleration of wound healing process, minimal scar formation, and the rates of wounds sterility.
A. A. Mahmood , K. Sidik , K. A. R. Suzainur , M. Indran and I. Salmah , 2005. Evaluation of In-Vivo Wound Healing Activity of Chromolaena Odorata Leaf Extract on Excision Wounds Model in Rats . Journal of Food Technology, 3: 126-129.